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Clinical Trial Report

Gene Therapy Trial Report

Summary

Safety and Efficacy of RRG001 Gene Therapy in Subjects With Neovascular Age-related Macular Degeneration (nAMD)


NCTID NCT06141460 (View at clinicaltrials.gov)
Description
Indication Neovascular (Wet) Age-Related Macular Degeneration
Compound Name RRG001
Sponsor Shanghai Refreshgene Technology Co., Ltd.
Funder Type Industry
Status
Recruiting
Enrollment Count 48

Therapy Information


Target Gene/Variant Anti-VEGF
Therapy Type Gene transfer
Therapy Route In-vivo
Mechanism of Action Genetic delivery of therapeutic protein
Route of Administration Subretinal
Drug Product Type Viral vector
Target Tissue/Cell
Delivery System Viral transduction
Vector Type AAV
Editor Type
Dose 1 Undisclosed dose 1
Dose 2 Undisclosed dose 2
Dose 3 Undisclosed dose 3
Dose 4 Undisclosed dose 4
Dose 5 Dose range: 1 x 10^8 - 1 x 10^13 vg/eye

Study Record Dates


Current Stage Phase1, Phase2
Submit Date 2023-11-10
Completion Date 2030-12-31
Last Update 2024-01-03

Participation Criteria


Eligible Age >=50 Years
Standard Ages Adult, Older adult
Eligible Sex ALL

Locations


No.of Trial Sites 1
Locations China

Regulatory Information


Has US IND False
Recent Updates

Resources/Links