On-target editing compared to 14 circle-seq nominated off-target sites of adenine base editor delivered by BE-eVLP vs AAV in the C57BL/6 liver |
OT13 (A6)-BE-eVLP |
adenine base editing at target Pcsk9 site in liver vs. other mouse organs (heart, kidney, lung, muscle, spleen) |
liver |
Editing Efficiency |
15000001545 |
|
TadA-8e V106W |
eVLP |
Virus Like Particle |
|
|
|
Mouse |
C57BL/6J |
|
intravenous, retro-orbital |
liver |
7E11 eVLPs |
once |
|
120 microliters |
1 week |
ribonucleoprotein (RNP) |
|
|
|
Measured Values |
Samples Size: | 4 |
|
Mean |
0.01  |
1 |
0.012986  |
2 |
0  |
3 |
0.01365  |
4 |
0.008243  |
| |
|