Amphiphilic Peptides Deliver Base Editor RNPs to Rhesus Monkey Airway |
S10 and ABE8e-Cas9 RNP |
Editing efficiency was assessed using Next Generation Sequencing of airway epithelial cells obtained by airway brushing in two airways of the airway tree |
left main bronchus |
bronchial epithelial cell |
Editing Efficiency |
15000002991 |
|
ABE8e-Cas9 |
S10 |
Amphiphilic peptide |
gRNA #8 |
|
|
Rhesus macaque |
Macaca mulatta (Rhesus Macaque) |
|
intra-tracheal instillation |
airway epithelium |
2 uM gRNA, 2.5 uM Cas9, 40 uM S10 amphiphilic peptide |
once |
n/a |
1 ml |
7 days |
ribonucleoprotein (RNP) |
|
|
|
Measured Values |
Samples Size: | 1 |
|
Mean |
0.03  |
1 |
0.032  |