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ExperimentIndependent validation of Chaikof delivery platform using virus-like particle (VLP) delivery to the mouse liver
Experiment ConditionFemale (Experimental)
Assay Description: Targeted next generation sequencing (NGS)
Tissue Measured:liver
Measurement Type:Editing Efficiency
Record ID15000003569

EditorABE8e
Delivery SystemeVLP
Delivery System SubtypeVirus Like Particle
GuidePcsk9 Exon 1 splice domain
Vector

Model SpeciesMouse
Model NameB6

Application Methodintravenous, tail vein
Application Siteliver
Dosage5E11 particles
Injection Frequencyonce
Injection Rate
Injection Volume100 microliters
Days post injection
Editor Formatribonucleoprotein (RNP)
Antidote Id
Antidote Description

Measured Values
Samples Size: 3
 
Replicate Result (Editing Efficiency)
Measurement Units: % of reads
Mean 54.83 
1 56.5 
2 48.4 
3 59.6