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Clinical Trial Report

Gene Therapy Trial Report

Summary

A Study of EXG102-031 in Patients With wAMD (Everest)


NCTID NCT05903794 (View at clinicaltrials.gov)
Description
Development Status Active
Indication Neovascular (Wet) Age-Related Macular Degeneration (nAMD)
Disease Ontology Term DOID:10871
Compound Name EXG102-031
Sponsor Exegenesis Bio
Funder Type Industry
Recruitment Status
Active not recruiting
Enrollment Count 12
Results Posted Not Available

Therapy Information


Target Gene/Variant ABD-VEGFR
Therapy Type Gene transfer
Therapy Route In-vivo
Mechanism of Action Genetic delivery of therapeutic protein
Route of Administration Subretinal
Drug Product Type Viral vector
Target Tissue/Cell
Delivery System Viral transduction
Vector Type AAV8
Editor Type none
Dose 1 Undisclosed dose 1
Dose 2 Undisclosed dose 2
Dose 3
Dose 4
Dose 5

Study Record Dates


Current Stage Phase1
Submit Date 2023-06-06
Completion Date 2026-02-28
Last Update 2025-04-17

Participation Criteria


Eligible Age >=50 Years
Standard Ages Adult, Older adult
Sexes Eligible for Study ALL

Locations


No.of Trial Sites 2
Locations United States

Regulatory Information


Has US IND True
FDA Designations
Recent Updates FDA cleared IND 1/18/23

Resources/Links