Program Snapshot

The goal of the SCGE program is to accelerate the development of safer and more effective methods to edit the genomes of disease-relevant somatic cells and tissues in patients.  For ethical, legal and safety reasons, the SCGE program does not support any research activities on genome editing in reproductive (germ) cells.

Goals by Initiative

In The News

Important COVID-19 Updates from the NIH

COVID-19 is an emerging, rapidly evolving situation.  Get the latest information here, including important prevention and mitigation strategies, and how to best protect you and you family.

Important information for laboratories can also be found here.

Thank you and stay safe!


Mary E. Shimoyama, PhD, associate professor of biomedical engineering, passed away on Feb. 19. She was 67.

Dr. Shimoyama has been involved with MCW’s Rat Genome Database since she first began working here in 2000, helping it evolve into the leading resource for rat genomic, genetic, phenotype and disease data. She earned her PhD in biomedical informatics from the University of Wisconsin-Milwaukee in 2011 and became an assistant professor of surgery at MCW. In 2016, she was promoted to associate professor in the Marquette University and MCW Joint Department of Biomedical Engineering. Dr. Shimoyama was exceptionally, and justifiably, proud of becoming the principal investigator for the Rat Genome Database and leading it through a recent competitive renewal. She was also honored to be the Vice Chair of Research and Clinical Affairs for the department this past year.


Search-and-replace genome editing without double-strand breaks or donor DNA

10/21/2019 – Congratulations to the Lui Group on the publishing of their exciting new article on prime editing which is a versatile and precise gene editing tool which was published today in Nature.

Please read the commentary by Heidi Ledford titled “Super-precise new CRISPR tool could tackle a plethora of genetic diseases” here.


NIH Awards $89 Million for Additional Projects to Advance Genome Editing

10/1/2019 – Genome editing is a promising technology that could offer new treatments or cures for diseases, but challenges remain. To help address them, the National Institutes of Health (NIH) has awarded 24 additional grants to researchers across the United States and Canada through the Somatic Cell Genome Editing (SCGE) Program.


Nano-Sized Solution for Efficient and Versatile CRISPR Gene Editing

9/17/2019 – If used to make non-heritable genetic changes, CRISPR gene-editing technology holds tremendous promise for treating or curing a wide range of devastating disorders, including sickle cell disease, vision loss, and muscular dystrophy. Early efforts to deliver CRISPR-based therapies to affected tissues in a patient’s body typically have involved packing the gene-editing tools into viral vectors, which may cause unwanted immune reactions and other adverse effects.