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The 15th annual CRISPR meeting will showcase cutting-edge research from leaders in the CRISPR field – from the discovery and characterization of new CRISPR-Cas and related defense systems, to structural and mechanistic insights, evolutionary and ecological considerations, and genome editing and other applications. This community meeting seeks to bring together scientists from around the world to share their passion and curiosity about these fascinating systems and serve as a forum for the exchange of ideas. The 2022 meeting will take place in Cambridge, Massachusetts, just across the river from Boston. Take a tip from the locals – we call it CRISPah here!