Key Inclusion Criteria: * Clinical and molecular diagnosis of retinitis pigmentosa caused by defect in PDE6B gene without other syndromic manifestations * Aged above 13 years * Ability to give informed consent Key Exclusion Criteria: * Previous ocular surgery or thermal laser within 6 months before the surgery * Lens opacities or obscured ocular media upon recruitment such reliable evaluation or grading of the posterior segment cannot be performed * Known serious allergies to the fluorescein dye used in angiography, to the mydriatic, steroidal and non-steroidal eye drops * Participation in another clinical trial with an investigational agent * Enrolled or being enrolled in another gene therapy clinical trial * Active, extraocular infection requiring the prolonged or chronic use of antimicrobial agents * Chronic medical conditions, cancer * Abnormal laboratory values * On immunosuppressive therapy