Remarkable developments in genome editing are revolutionizing medicine and agriculture as large animal genomes can, for the first time, be modified with sophistication and efficiency so far only achievable in the mouse. This technology allows for improvement in livestock production traits, agricultural animal health and welfare, and generation of more refined large animal models for biomedical applications. The summit will bring together reproductive biologists, geneticists, molecular biologists, animal model developers, preclinical and clinical researchers, and representatives of federal research and regulatory agencies.