The Collaboration Opportunity Fund (COF) is meant to promote the exchange, cross-testing and evaluation of the improved technologies within the Somatic Cell Genome Editing (SCGE) Consortium. The COF will support new and pilot research projects led by SCGE-supported investigators.
| Year | Title | Collaborators | Collaboration Institution |
|---|---|---|---|
| 2019-2020 | Evaluation of LNP-based nanoparticles for systematic delivery of base editors | Peter Glazer, MD PhD | Yale University |
| W. Mark Saltzman, PhD | Yale University | ||
| Alice Tarantal, PhD | University of California at Davis | ||
| 2019-2020 | Improved reporters to evaluate base editor activity in mice | Steve Murray, PhD | Jackson Laboratory |
| David Liu, PhD | Broad Institute | ||
| 2019-2020 | Development of a GFP-IVS2 Mouse Reporter Strain for PNA-based Genome Editing Detection | Steve Murray, PhD | Jackson Laboratory |
| Peter Glazer, MD PhD | Yale University | ||
| 2019-2020 | Nanoparticles delivery of new Cas enzymes | Niren Murthy, PhD | University of California Berkeley |
| Jennifer Doudna, PhD | University of California Berkeley | ||
| 2019-2020 | Comparing the efficiency and cellular impact of non-viral, hepatocyte-targeted delivery vehicles with viral-mediated gene delivery in a microphysiological liver on chip platform | Samira Kiani, PhD | University of Pittsburgh |
| Shaoqin Gong, PhD | University of Wisconsin-Madison | ||
| Ross Wilson, PhD | University of California Berkeley | ||
| 2019-2020 | Non-enzymatic gene editing of hematopoietic cells in utero in nonhuman primates by next generation PNA nanoparticles | Zheng-Yi Chen, PhD | Massachusetts Eye and Ear Infirmary |
| Qiaobing Xu, PhD | Tufts University | ||
| David Liu, PhD | Broad Institute | ||
| 2019-2020 | Adenine Base Editor Ribonucleoprotein Delivery to Primary Airway Epithelia using Amphiphilic Peptids | Paul McCray, MD | University of Iowa |
| Alice Tarantal, PhD | University of California at Davis | ||
| David Liu, PhD | Broad Institute | ||
| David Guay, PhD | Feldan Institute | ||
| 2019-2020 | RNP delivery platforms for biodistribution of genome editors to human neural microtissues | Todd McDevitt, PhD | Gladstone Institute |
| Ross Wilson, PhD | University of California Berkeley | ||
| 2020-2021 | Guide Engineering to Enhance the Safety and Efficacy of Base Editing in vivo | Erik Sontheimer, PhD | University of Massachusetts Medical School |
| David Liu, PhD | Broad Institute | ||
| 2020-2021 | Development of a single AAV vector CRISPR-CasĪ¦ platform technology | Jennifer Doudna, PhD | University of California Berkeley |
| David Liu, PhD | Broad Institute | ||
| Ben Deverman, PhD | Broad Institute | ||
| 2020-2021 | Novel virus-like particles (VLPs) for precise delivery of base-editors in iPSC disease models | Bruce Conklin, MD | Gladstone Institute |
| Jennifer Doudna, PhD | University of California Berkeley | ||
| 2020-2021 | Cas9 ribonucleoprotein delivery targeted to kidney epithelium | Ross Wilson, PhD | University of California Berkeley |
| Benjamin Freedman, PhD | University of Washington | ||
| 2020-2021 | Developing methods for unbiased off-target genome editing analysis in vivo | Scot Wolfe, PhD | University of Massachusetts Medical School |
| Wen Xue, PhD | University of Massachusetts Medical School | ||
| 2020-2021 | Improving Split AAV9 Base Editors In Mice | Cathleen Lutz, PhD | Jackson Laboratory |
| David Liu, PhD | Broad Institute | ||
| 2020-2021 | CEST based imaging of Cas9-b-lactamase fusion proteins | Niren Murthy, PhD | University of California Berkeley |
| Moriel Vandsburger, PhD | University of California Berkeley | ||
| 2021-2022 | Assessment of Prime Editing in Rhesus Monkeys | David Liu, PhD | Broad Institute |
| Alice Tarantal, PhD | University of California at Davis | ||
| 2021-2022 | Enhanced in vivo editing of the endothelium via a novel adenovirus-AAV chimera vector | David Curiel, MD PhD | Washington University in St. Louis |
| Gang Bao, PhD | Rice University | ||
| Bill Lagor, PhD | Baylor College of Medicine | ||
| 2021-2022 | Identification and optimization of shuttle peptides-mediated local RNP delivery of editing complex in the sensory organs of the inner ear and retina in vivo in mice and the pig | Zheng-Yi Chen, PhD | Massachusetts Eye and Ear Infirmary |
| David Guay, PhD | Feldan Institute | ||
| 2021-2022 | Nanoparticle-based delivery of Mitochondrial Based Editors | Steve Ekker, PhD | Mayo Clinic |
| Sarah Gong, PhD | University of Wisconsin-Madison | ||
| 2021-2022 | Libraries of Cas9-mRNA nanoparticles in human iPSC-derived neurons | Bruce Conklin, MD | Gladstone Institute |
| James Dahlman, PhD | Georgia Institute of Technology | ||
| 2021-2022 | Editing the Kidney Epigenome | Beno Freedman, PhD | University of Washington |
| Charlie Gersbach, PhD | Duke University | ||
| Aravind Asokan, PhD | Duke University | ||
| 2021-2022 | Evaluation of Immune Responses to Novel Editors in Rhesus Monkeys | Jennifer Doudna, PhD | University of California Berkeley |
| Alice Tarantal, PhD | University of California at Davis |