Hallmarks of Cancer Cell Symposium is one of the most popular and longest-lasting conference series of Cell Press, and has been successfully held in the United States, Europe, and China previously. High-quality talks from highly respected cancer researchers and oncologists will strengthen and extend our understanding of cancer biology and accelerate the translation of the cutting-edge knowledge into more effective therapies. As a tradition, our “Meet the Speakers” dinner provides an additional great platform to communicate with leaders in the community in an interactive, productive, and relaxed environment. The year of 2022 also marks the 20th anniversary of Cancer Cell, and the meeting attendees are all invited to join our celebration of 20 years of serving this great community. After the disruption in scientific communication and social isolation imposed by lockdowns and travel restrictions, we are excited to meet you and talk about science in person. Come and join us in San Diego this fall.