The Collaboration Opportunity Fund (COF) is meant to promote the exchange, cross-testing and evaluation of the improved technologies within the Somatic Cell Genome Editing (SCGE) Consortium. The COF will support new and pilot research projects led by SCGE-supported investigators.

YearTitleCollaboratorsCollaboration Institution
2019-2020Evaluation of LNP-based nanoparticles for systematic delivery of base editorsPeter Glazer, MD PhDYale University
W. Mark Saltzman, PhDYale University
Alice Tarantal, PhDUniversity of California at Davis
2019-2020Improved reporters to evaluate base editor activity in miceSteve Murray, PhDJackson Laboratory
David Liu, PhDBroad Institute
2019-2020Development of a GFP-IVS2 Mouse Reporter Strain for PNA-based Genome Editing DetectionSteve Murray, PhDJackson Laboratory
Peter Glazer, MD PhDYale University
2019-2020Nanoparticles delivery of new Cas enzymesNiren Murthy, PhDUniversity of California Berkeley
Jennifer Doudna, PhDUniversity of California Berkeley
2019-2020Comparing the efficiency and cellular impact of non-viral, hepatocyte-targeted delivery vehicles with viral-mediated gene delivery in a microphysiological liver on chip platformSamira Kiani, PhDUniversity of Pittsburgh
Shaoqin Gong, PhDUniversity of Wisconsin-Madison
Ross Wilson, PhDUniversity of California Berkeley
2019-2020Non-enzymatic gene editing of hematopoietic cells in utero in nonhuman primates by next generation PNA nanoparticlesZheng-Yi Chen, PhDMassachusetts Eye and Ear Infirmary
Qiaobing Xu, PhDTufts University
David Liu, PhDBroad Institute
2019-2020Adenine Base Editor Ribonucleoprotein Delivery to Primary Airway Epithelia using Amphiphilic PeptidsPaul McCray, MDUniversity of Iowa
Alice Tarantal, PhDUniversity of California at Davis
David Liu, PhDBroad Institute
David Guay, PhDFeldan Institute
2019-2020RNP delivery platforms for biodistribution of genome editors to human neural microtissuesTodd McDevitt, PhDGladstone Institute
Ross Wilson, PhDUniversity of California Berkeley
2020-2021Guide Engineering to Enhance the Safety and Efficacy of Base Editing in vivoErik Sontheimer, PhDUniversity of Massachusetts Medical School
David Liu, PhDBroad Institute
2020-2021Development of a single AAV vector CRISPR-CasĪ¦ platform technologyJennifer Doudna, PhDUniversity of California Berkeley
David Liu, PhDBroad Institute
Ben Deverman, PhDBroad Institute
2020-2021Novel virus-like particles (VLPs) for precise delivery of base-editors in iPSC disease modelsBruce Conklin, MDGladstone Institute
Jennifer Doudna, PhDUniversity of California Berkeley
2020-2021Cas9 ribonucleoprotein delivery targeted to kidney epitheliumRoss Wilson, PhDUniversity of California Berkeley
Benjamin Freedman, PhDUniversity of Washington
2020-2021Developing methods for unbiased off-target genome editing analysis in vivoScot Wolfe, PhDUniversity of Massachusetts Medical School
Wen Xue, PhDUniversity of Massachusetts Medical School
2020-2021Improving Split AAV9 Base Editors In MiceCathleen Lutz, PhDJackson Laboratory
David Liu, PhDBroad Institute
2020-2021CEST based imaging of Cas9-b-lactamase fusion proteinsNiren Murthy, PhDUniversity of California Berkeley
Moriel Vandsburger, PhDUniversity of California Berkeley
2021-2022Assessment of Prime Editing in Rhesus MonkeysDavid Liu, PhDBroad Institute
Alice Tarantal, PhDUniversity of California at Davis
2021-2022Enhanced in vivo editing of the endothelium via a novel adenovirus-AAV chimera vectorDavid Curiel, MD PhDWashington University in St. Louis
Gang Bao, PhDRice University
Bill Lagor, PhDBaylor University
2021-2022Identification and optimization of shuttle peptides-mediated local RNP delivery of editing compex in the sensory organs of the inner ear and retina in vivo in mice and the pigZheng-Yi Chen, PhDMassachusetts Eye and Ear Infirmary
David Guay, PhDFeldan Institute
2021-2022Nanoparticle-based delivery of Mitochondrial Based EditorsSteve Ekker, PhDMayo Clinic
Sarah Gong, PhDUniversity of Wisconsin-Madison
2021-2022Libraries of Cas9-mRNA nanoparticles in human iPSC-derived neuronsBruce Conklin, MDGladstone Institute
James Dahlman, PhDGeorgia Institute of Technology
2021-2022Editing the Kidney EpigenomeBeno Freedman, PhDUniversity of Washington
Charlie Gersbach, PhDDuke University
Aravind Asokan, PhDDuke University
2021-2022Evaluation of Immune Responses to Novel Editors in Rhesus MonkeysJennifer Doudna, PhDUniversity of California Berkeley
Alice Tarantal, PhDUniversity of California at Davis