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Organoids as Tools for Fundamental Discovery and Translation
Organoids are complex three-dimensional in vitro organ-like model systems. Organoids can be derived from pluripotent stem cells or primary donor tissue and have been used to address fundamental questions about development, stem cell biology and organ regeneration. Human organoids have highlighted significant unknowns in human biology and have invigorated new exploration into the cellular makeup of human organs during development, in the adult and during disease.