Experiment Biomarker assays to evaluate toxicity and inflammation induced by AAVs in ES cell derived kidney organoids. Experiment Condition AAV2/8 Assay Description: KIM-1 and MCP-1 levels were measured using the Meso Scale Discovery (MSD) platform Tissue Measured: Measurement Type: Biomarker Detection Record ID 15000003426 Editor Delivery System AAV Delivery System Subtype Viral vector Guide Vector AAV2/8CMVeGFP; Model Species Human Model Name Human kidney organoid (ESC-derived) Application Method Virus Application Site Dosage MOI=10^5 Injection Frequency Injection Rate Injection Volume Days post injection 7 days Editor Format AAV encoded Antidote Id Antidote Description Measured Values Samples Size: 3   Replicate Result (Biomarker Detection) Measurement Units: KIM-1 (pg/mL) Mean 0  1 0  2 0  3 0  Measurement Units: MCP-1 (pg/mL) Mean 627.16  1 627.4  2 628.27  3 625.8