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62 results in Vectors

AAV6-ZsGreen-Cre - Vector - [In Vivo] [AAV tropism] [Mouse] Matched on: category --> Vector AAV backbone with a bi-directional promoter driving zsGreen and Cre Experiments AAV Tropism project
AAV9-Ai9-sgRNA2-CB-SaCas9 - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV serotype 9 delivering gRNA 2 + CB SaCas9 targeting the Ai9 locus Experiments Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 Cas9 to sgRNA ratio (CB promoter)
AAVcc47-Ai9-sgRNA1 + sgRNA2 - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV serotype 9 delivering u6 promoter driving sgRNA 1 + sgRNA2 targeting the Ai9 locus Experiments Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 cas9 to sgRNA ratio (CMV promoter) Comparing CRISPR/Cas9 gene editing efficiencies between AAV9 and AAVcc47 in Ai9 mice with a 1:3 Cas9 to sgRNA ratio (CMV promoter)
AAVcc84-GFP - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV2/9 self complementary vector with capsid variant cc84 expressing GFP driven by CBh promoter Experiments Testing virus region 8 (VR8) mutant cross-species compatible Adeno Associated Viruses (ccAAVs) in mice.
AAV-CMV-SaCas9-U6-gRNA-LoxP-Sa-L1 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
AAV-CMV-SaCas9-U6-gRNA-LoxP-Sa-L2 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
AAVrh10-ZsGreen-Cre - Vector - [In Vivo] [AAV tropism] [Mouse] Matched on: category --> Vector AAV backbone with a bi-directional promoter driving zsGreen and Cre Experiments AAV Tropism project
AAVrh74-ZsGreen-Cre - Vector - [In Vivo] [AAV tropism] [Mouse] Matched on: category --> Vector AAV backbone with a bi-directional promoter driving zsGreen and Cre Experiments AAV Tropism project
demo VV02-Cre - Vector - [In Vivo] [DCC] [Mouse] Matched on: category --> Vector DEMO viral vector for demo purpose Experiments MOCK VIRUS TROPISM STUDY For Toolkit demonstration purposes only
scAAV5-Cre-GFP - Vector - [In Vivo] [Small Animal Testing Center (SATC)] [Mouse] Matched on: category --> Vector Experiments Validation for Gao Delivery Team: Testing ssAAV5 delivered intratracheally for editing activity in lung epithelia in Ai9 mice
AAV9-GFP - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV2/9 self complementary vector expressing GFP driven by CBh promoter Experiments Testing virus region 8 (VR8) mutant cross-species compatible Adeno Associated Viruses (ccAAVs) in mice.
AAV9-mCherry - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV2/9 self complementary vector expressing Mcherry driven by CBh promoter Experiments Testing virus region 4 (VR4) mutant cross-species compatible Adeno Associated Viruses (ccAAVs) in mice.
AAVcc47-CMV-SaCas9 - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAVcc47 delivering CMV driven SaCas9 Experiments Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 cas9 to sgRNA ratio (CMV promoter) Comparing CRISPR/Cas9 gene editing efficiencies between AAV9 and AAVcc47 in Ai9 mice with a 1:3 Cas9 to sgRNA ratio (CMV promoter)
AAVcc47-SaCas9-Ai9 - Vector - [In Vivo] [Small Animal Testing Center (SATC)] [Mouse] Matched on: category --> Vector AAV2/9 expressing SaCas9 and single sgRNA under U6 promoter Experiments Validation for Asokan Delivery Team: Evolving High Potency AAV Vectors for Neuromuscular Genome Editing.
AAV-CMV-SaCas9-U6-modified scaffold-Sa-L1 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA with modified scaffold sequence Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
AAV-CMV-SaCas9-U6-modified scaffold-Sa-LoxP2 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA with modified scaffold sequence Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
AAV-Pcsk9 - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector Experiments On-target editing compared to 14 circle-seq nominated off-target sites of adenine base editor delivered by BE-eVLP vs AAV in the C57BL/6 liver
pH509 AAVsc-u6-sgAI9L-U6-AI9R-U1A-EGFP (1) - Vector - [In Vitro] [Delivery Systems Initiative] [Human] Matched on: category --> Vector AAV2/5 expressing SpyCas9. AAV2/5 expressing two sgRNAs under U6 promoter and eGFP Experiments Testing AAV5 for activation of tdTomato in HEK293T cells
AAV3b-ZsGreen-Cre - Vector - [In Vivo] [AAV tropism] [Mouse] Matched on: category --> Vector AAV backbone with a bi-directional promoter driving zsGreen and Cre Experiments AAV Tropism project
AAV5-ZsGreen-Cre - Vector - [In Vivo] [AAV tropism] [Mouse] Matched on: category --> Vector AAV backbone with a bi-directional promoter driving zsGreen and Cre Experiments AAV Tropism project
AAV8-ZsGreen-Cre - Vector - [In Vivo] [AAV tropism] [Mouse] Matched on: category --> Vector AAV backbone with a bi-directional promoter driving zsGreen and Cre Experiments AAV Tropism project
AAV9-Ai9-sgRNA1-CB-SaCas9 - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV serotype 9 delivering sgRNA 1 + CB SaCas9 targeting the Ai9 locus Experiments Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 Cas9 to sgRNA ratio (CB promoter)
AAVcc47-Ai9-sgRNA2-CB-SaCas9 - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAVcc47 delivering sgRNA 2 + CB SaCas9 targeting the Ai9 locus Experiments Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 Cas9 to sgRNA ratio (CB promoter)
AAVcc47-Cre - Vector - [In Vivo] [Small Animal Testing Center (SATC)] [Mouse] Matched on: category --> Vector AAV2/5 expressing Cre recombinase Experiments Validation for Asokan Delivery Team: Evolving High Potency AAV Vectors for Neuromuscular Genome Editing.
AAVcc81-GFP - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV2/9 self complementary vector with capsid variant cc81 expressing GFP driven by CBh promoter Experiments Testing virus region 8 (VR8) mutant cross-species compatible Adeno Associated Viruses (ccAAVs) in mice.
AAV-CMV-SaCas9-U6-gRNA-LoxP-Sa-LoxP1 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
AAV-CMV-SaCas9-U6-gRNA-LoxP-Sa-LoxP2 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
AAV-CMV-SaCas9-U6-modified scaffold-Sa-L3 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA with modified scaffold sequence Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
AAV.pU1a-SpCas9 - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector Expresses codon-optimized SpCas9 in mammalian cells. HA-SV40NLS-SpCas9-SV40NLS Experiments Testing AAV5 for activation of tdTomato in mouse airway Testing AAV5 for activation of tdTomato in mouse airway club and ciliated cells
BI28:AAV-GFAP-SaCas9-WPRE3-pA - Vector - [In Vivo] [Small Animal Testing Center (SATC), Delivery Systems Initiative] [Mouse] Matched on: category --> Vector Novel engineered AAV BI28 variant expressing S. aureus Cas9 driven by the glial fibrillary acidic protein (GFAP) promoter Experiments Testing gRNA sequence and gRNA scaffold modified in Ai9 mice. Second site validation of Deverman delivery platform using engineered AAVs to deliver CRSIPR/Cas9 to mouse brain
demo VV05-Cre - Vector - [In Vivo] [DCC] [Mouse] Matched on: category --> Vector DEMO viral vector for demo purpose Experiments MOCK VIRUS TROPISM STUDY For Toolkit demonstration purposes only
pPP444 - Vector - [In Vitro] [Genome Editors] [Human] Matched on: category --> Vector Plasmid containing Homo sapiens codon optimized CasΦ-3 and spacer for editing in human cells. Experiments Testing newly discovered Biggie Phage editors in human cells
ssAAV5-sgA+sgB-U1A.GFP - Vector - [In Vivo] [Small Animal Testing Center (SATC)] [Mouse] Matched on: category --> Vector Experiments Validation for Gao Delivery Team: Testing ssAAV5 delivered intratracheally for editing activity in lung epithelia in Ai9 mice
ssAAV5-sgB.saCas9 - Vector - [In Vivo] [Small Animal Testing Center (SATC)] [Mouse] Matched on: category --> Vector Experiments Validation for Gao Delivery Team: Testing ssAAV5 delivered intratracheally for editing activity in lung epithelia in Ai9 mice
ssAAV5-spCas9 - Vector - [In Vivo] [Small Animal Testing Center (SATC)] [Mouse] Matched on: category --> Vector Experiments Validation for Gao Delivery Team: Testing ssAAV5 delivered intratracheally for editing activity in lung epithelia in Ai9 mice
AAV4-ZsGreen-Cre - Vector - [In Vivo] [AAV tropism] [Mouse] Matched on: category --> Vector AAV backbone with a bi-directional promoter driving zsGreen and Cre Experiments AAV Tropism project
AAV9-CMV-SaCas9 - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV serotype 9 delivering CMV driven SaCas9 Experiments Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 cas9 to sgRNA ratio (CMV promoter) Comparing CRISPR/Cas9 gene editing efficiencies between AAV9 and AAVcc47 in Ai9 mice with a 1:3 Cas9 to sgRNA ratio (CMV promoter) Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 Cas9 to sgRNA ratio (CMV promoter) and self complementary sgRNA vector.
AAV9-ZsGreen-Cre - Vector - [In Vivo] [AAV tropism] [Mouse] Matched on: category --> Vector AAV backbone with a bi-directional promoter driving zsGreen and Cre Experiments AAV Tropism project
AAVcc47-Ai9-sgRNA1-CB-SaCas9 - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAVcc47 delivering sgRNA 1 + CB SaCas9 targeting the Ai9 locus Experiments Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 Cas9 to sgRNA ratio (CB promoter)
AAVcc47-CMV-Cre - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAVcc47 delivering CMV Cre Recombinase Experiments Cre Recombinase dose escalation study in Ai9 mice
AAVcc47_pTR_self comp 2xU6-Ai9 guides - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAVcc47 delivering u6 promoter driving sgRNA 1 + sgRNA2 (self complementray vector) targeting Ai9 transgene Experiments Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 Cas9 to sgRNA ratio (CMV promoter) and self complementary sgRNA vector.
AAV-CMV-SaCas9-U6-gRNA-LoxP-Sa-R1 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
AAV-CMV-SaCas9-U6-gRNA-LoxP-Sa-R2 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
AAV-CMV-SaCas9-U6-modified scaffold-Sa-L2 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA with modified scaffold sequence Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
AAVrh8-ZsGreen-Cre - Vector - [In Vivo] [AAV tropism] [Mouse] Matched on: category --> Vector AAV backbone with a bi-directional promoter driving zsGreen and Cre Experiments AAV Tropism project
demo VV03-Cre - Vector - [In Vivo] [DCC] [Mouse] Matched on: category --> Vector DEMO viral vector for demo purpose Experiments MOCK VIRUS TROPISM STUDY For Toolkit demonstration purposes only
demo VV04-Cre - Vector - [In Vivo] [DCC] [Mouse] Matched on: category --> Vector DEMO viral vector for demo purpose Experiments MOCK VIRUS TROPISM STUDY For Toolkit demonstration purposes only
pPP394 - Vector - [In Vitro] [Genome Editors] [Human] Matched on: category --> Vector Plasmid containing Homo sapiens codon optimized CasΦ-1 and spacer for editing in human cells. Experiments Testing newly discovered Biggie Phage editors in human cells
AAV7-ZsGreen-Cre - Vector - [In Vivo] [AAV tropism] [Mouse] Matched on: category --> Vector AAV backbone with a bi-directional promoter driving zsGreen and Cre Experiments AAV Tropism project
AAV9-Ai9-sgRNA1 + sgRNA2 - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV serotype 9 delivering u6 promoter driving sgRNA 1 + sgRNA2 targeting the Ai9 locus Experiments Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 cas9 to sgRNA ratio (CMV promoter) Comparing CRISPR/Cas9 gene editing efficiencies between AAV9 and AAVcc47 in Ai9 mice with a 1:3 Cas9 to sgRNA ratio (CMV promoter)
AAV9-CMV-Cre - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV serotype 9 delivering CMV Cre Recombinase Experiments Cre Recombinase dose escalation study in Ai9 mice
AAV9_pTR_self comp 2xU6-Ai9 guides - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV serotype 9 delivering u6 promoter driving sgRNA 1 + sgRNA2 (self complementray vector) targeting Ai9 transgene Experiments Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 Cas9 to sgRNA ratio (CMV promoter) and self complementary sgRNA vector.
AAVcc47-mCherry - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV2/9 self complementary vector with capsid variant cc47 expressing Mcherry driven by CBh promoter Experiments Testing virus region 4 (VR4) mutant cross-species compatible Adeno Associated Viruses (ccAAVs) in mice.
AAV-CMV-SaCas9-U6-gRNA-LoxP-Sa-L3 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
AAV-CMV-SaCas9-U6-modified scaffold-Sa-LoxP1 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA with modified scaffold sequence Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
AAV-CMV-SaCas9-U6-modified scaffold-Sa-R1 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA with modified scaffold sequence Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
AAV-CMV-SaCas9-U6-modified scaffold-Sa-R2 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA with modified scaffold sequence Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
BI28:AAV-GFAP-NLS-GFP-WPRE-synpA-L1-R2 - Vector - [In Vivo] [Small Animal Testing Center (SATC), Delivery Systems Initiative] [Mouse] Matched on: category --> Vector Novel engineered AAV BI28 variant expressing NLS-GFP driven by the glial fibrillary acidic protein (GFAP) promoter and dual sgRNAs with modified scaffolds Experiments Testing gRNA sequence and gRNA scaffold modified in Ai9 mice. Second site validation of Deverman delivery platform using engineered AAVs to deliver CRSIPR/Cas9 to mouse brain
demo VV01-Cre - Vector - [In Vivo] [DCC] [Mouse] Matched on: category --> Vector DEMO viral vector for demo purpose Experiments MOCK VIRUS TROPISM STUDY For Toolkit demonstration purposes only
H509 AAVsc-u6-sgAI9L-U6-AI9R-U1A-EGFP (1) - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse] Matched on: category --> Vector AAV2/5 expressing SpyCas9. AAV2/5 expressing two sgRNAs under U6 promoter and eGFP Experiments Testing AAV5 for activation of tdTomato in mouse airway Testing AAV5 for activation of tdTomato in mouse airway club and ciliated cells
pAAV.pU1a-SpCas9 - Vector - [In Vitro] [Delivery Systems Initiative] [Human] Matched on: category --> Vector Expresses codon-optimized SpCas9 in mammalian cells. HA-SV40NLS-SpCas9-SV40NLS Experiments Testing AAV5 for activation of tdTomato in HEK293T cells
pPP441 - Vector - [In Vitro] [Genome Editors] [Human] Matched on: category --> Vector Plasmid containing Homo sapiens codon optimized CasΦ-2 and spacer for editing in human cells. Experiments Testing newly discovered Biggie Phage editors in human cells

62 results in Vectors

Category	Type	Name	Description	View Associated..
Vector	Viral Vector	AAV6-ZsGreen-Cre	AAV backbone with a bi-directional promoter driving zsGreen and Cre	Experiments AAV Tropism project
Vector	Viral Vector	AAV9-Ai9-sgRNA2-CB-SaCas9	AAV serotype 9 delivering gRNA 2 + CB SaCas9 targeting the Ai9 locus	Experiments Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 Cas9 to sgRNA ratio (CB promoter)
Vector	Viral Vector	AAVcc47-Ai9-sgRNA1 + sgRNA2	AAV serotype 9 delivering u6 promoter driving sgRNA 1 + sgRNA2 targeting the Ai9 locus	Experiments Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 cas9 to sgRNA ratio (CMV promoter) Comparing CRISPR/Cas9 gene editing efficiencies between AAV9 and AAVcc47 in Ai9 mice with a 1:3 Cas9 to sgRNA ratio (CMV promoter)
Vector	Viral Vector	AAVcc84-GFP	AAV2/9 self complementary vector with capsid variant cc84 expressing GFP driven by CBh promoter	Experiments Testing virus region 8 (VR8) mutant cross-species compatible Adeno Associated Viruses (ccAAVs) in mice.
Vector	Viral Vector	AAV-CMV-SaCas9-U6-gRNA-LoxP-Sa-L1	AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA	Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
Vector	Viral Vector	AAV-CMV-SaCas9-U6-gRNA-LoxP-Sa-L2	AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA	Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
Vector	Viral Vector	AAVrh10-ZsGreen-Cre	AAV backbone with a bi-directional promoter driving zsGreen and Cre	Experiments AAV Tropism project
Vector	Viral Vector	AAVrh74-ZsGreen-Cre	AAV backbone with a bi-directional promoter driving zsGreen and Cre	Experiments AAV Tropism project
Vector	Viral Vector	demo VV02-Cre	DEMO viral vector for demo purpose	Experiments MOCK VIRUS TROPISM STUDY For Toolkit demonstration purposes only
Vector	Viral Vector	scAAV5-Cre-GFP		Experiments Validation for Gao Delivery Team: Testing ssAAV5 delivered intratracheally for editing activity in lung epithelia in Ai9 mice
Vector	Viral Vector	AAV9-GFP	AAV2/9 self complementary vector expressing GFP driven by CBh promoter	Experiments Testing virus region 8 (VR8) mutant cross-species compatible Adeno Associated Viruses (ccAAVs) in mice.
Vector	Viral Vector	AAV9-mCherry	AAV2/9 self complementary vector expressing Mcherry driven by CBh promoter	Experiments Testing virus region 4 (VR4) mutant cross-species compatible Adeno Associated Viruses (ccAAVs) in mice.
Vector	Viral Vector	AAVcc47-CMV-SaCas9	AAVcc47 delivering CMV driven SaCas9	Experiments Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 cas9 to sgRNA ratio (CMV promoter) Comparing CRISPR/Cas9 gene editing efficiencies between AAV9 and AAVcc47 in Ai9 mice with a 1:3 Cas9 to sgRNA ratio (CMV promoter)
Vector	Viral Vector	AAVcc47-SaCas9-Ai9	AAV2/9 expressing SaCas9 and single sgRNA under U6 promoter	Experiments Validation for Asokan Delivery Team: Evolving High Potency AAV Vectors for Neuromuscular Genome Editing.
Vector	Viral Vector	AAV-CMV-SaCas9-U6-modified scaffold-Sa-L1	AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA with modified scaffold sequence	Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
Vector	Viral Vector	AAV-CMV-SaCas9-U6-modified scaffold-Sa-LoxP2	AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA with modified scaffold sequence	Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
Vector	Viral Vector	AAV-Pcsk9		Experiments On-target editing compared to 14 circle-seq nominated off-target sites of adenine base editor delivered by BE-eVLP vs AAV in the C57BL/6 liver
Vector	Viral Vector	pH509 AAVsc-u6-sgAI9L-U6-AI9R-U1A-EGFP (1)	AAV2/5 expressing SpyCas9. AAV2/5 expressing two sgRNAs under U6 promoter and eGFP	Experiments Testing AAV5 for activation of tdTomato in HEK293T cells
Vector	Viral Vector	AAV3b-ZsGreen-Cre	AAV backbone with a bi-directional promoter driving zsGreen and Cre	Experiments AAV Tropism project
Vector	Viral Vector	AAV5-ZsGreen-Cre	AAV backbone with a bi-directional promoter driving zsGreen and Cre	Experiments AAV Tropism project
Vector	Viral Vector	AAV8-ZsGreen-Cre	AAV backbone with a bi-directional promoter driving zsGreen and Cre	Experiments AAV Tropism project
Vector	Viral Vector	AAV9-Ai9-sgRNA1-CB-SaCas9	AAV serotype 9 delivering sgRNA 1 + CB SaCas9 targeting the Ai9 locus	Experiments Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 Cas9 to sgRNA ratio (CB promoter)
Vector	Viral Vector	AAVcc47-Ai9-sgRNA2-CB-SaCas9	AAVcc47 delivering sgRNA 2 + CB SaCas9 targeting the Ai9 locus	Experiments Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 Cas9 to sgRNA ratio (CB promoter)
Vector	Viral Vector	AAVcc47-Cre	AAV2/5 expressing Cre recombinase	Experiments Validation for Asokan Delivery Team: Evolving High Potency AAV Vectors for Neuromuscular Genome Editing.
Vector	Viral Vector	AAVcc81-GFP	AAV2/9 self complementary vector with capsid variant cc81 expressing GFP driven by CBh promoter	Experiments Testing virus region 8 (VR8) mutant cross-species compatible Adeno Associated Viruses (ccAAVs) in mice.
Vector	Viral Vector	AAV-CMV-SaCas9-U6-gRNA-LoxP-Sa-LoxP1	AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA	Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
Vector	Viral Vector	AAV-CMV-SaCas9-U6-gRNA-LoxP-Sa-LoxP2	AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA	Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
Vector	Viral Vector	AAV-CMV-SaCas9-U6-modified scaffold-Sa-L3	AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA with modified scaffold sequence	Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
Vector	Viral Vector	AAV.pU1a-SpCas9	Expresses codon-optimized SpCas9 in mammalian cells. HA-SV40NLS-SpCas9-SV40NLS	Experiments Testing AAV5 for activation of tdTomato in mouse airway Testing AAV5 for activation of tdTomato in mouse airway club and ciliated cells
Vector	Viral Vector	BI28:AAV-GFAP-SaCas9-WPRE3-pA	Novel engineered AAV BI28 variant expressing S. aureus Cas9 driven by the glial fibrillary acidic protein (GFAP) promoter	Experiments Testing gRNA sequence and gRNA scaffold modified in Ai9 mice. Second site validation of Deverman delivery platform using engineered AAVs to deliver CRSIPR/Cas9 to mouse brain
Vector	Viral Vector	demo VV05-Cre	DEMO viral vector for demo purpose	Experiments MOCK VIRUS TROPISM STUDY For Toolkit demonstration purposes only
Vector	Expression Plasmid	pPP444	Plasmid containing Homo sapiens codon optimized CasΦ-3 and spacer for editing in human cells.	Experiments Testing newly discovered Biggie Phage editors in human cells
Vector	Viral Vector	ssAAV5-sgA+sgB-U1A.GFP		Experiments Validation for Gao Delivery Team: Testing ssAAV5 delivered intratracheally for editing activity in lung epithelia in Ai9 mice
Vector	Viral Vector	ssAAV5-sgB.saCas9		Experiments Validation for Gao Delivery Team: Testing ssAAV5 delivered intratracheally for editing activity in lung epithelia in Ai9 mice
Vector	Viral Vector	ssAAV5-spCas9		Experiments Validation for Gao Delivery Team: Testing ssAAV5 delivered intratracheally for editing activity in lung epithelia in Ai9 mice
Vector	Viral Vector	AAV4-ZsGreen-Cre	AAV backbone with a bi-directional promoter driving zsGreen and Cre	Experiments AAV Tropism project
Vector	Viral Vector	AAV9-CMV-SaCas9	AAV serotype 9 delivering CMV driven SaCas9	Experiments Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 cas9 to sgRNA ratio (CMV promoter) Comparing CRISPR/Cas9 gene editing efficiencies between AAV9 and AAVcc47 in Ai9 mice with a 1:3 Cas9 to sgRNA ratio (CMV promoter) Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 Cas9 to sgRNA ratio (CMV promoter) and self complementary sgRNA vector.
Vector	Viral Vector	AAV9-ZsGreen-Cre	AAV backbone with a bi-directional promoter driving zsGreen and Cre	Experiments AAV Tropism project
Vector	Viral Vector	AAVcc47-Ai9-sgRNA1-CB-SaCas9	AAVcc47 delivering sgRNA 1 + CB SaCas9 targeting the Ai9 locus	Experiments Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 Cas9 to sgRNA ratio (CB promoter)
Vector	Viral Vector	AAVcc47-CMV-Cre	AAVcc47 delivering CMV Cre Recombinase	Experiments Cre Recombinase dose escalation study in Ai9 mice
Vector	Viral Vector	AAVcc47_pTR_self comp 2xU6-Ai9 guides	AAVcc47 delivering u6 promoter driving sgRNA 1 + sgRNA2 (self complementray vector) targeting Ai9 transgene	Experiments Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 Cas9 to sgRNA ratio (CMV promoter) and self complementary sgRNA vector.
Vector	Viral Vector	AAV-CMV-SaCas9-U6-gRNA-LoxP-Sa-R1	AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA	Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
Vector	Viral Vector	AAV-CMV-SaCas9-U6-gRNA-LoxP-Sa-R2	AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA	Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
Vector	Viral Vector	AAV-CMV-SaCas9-U6-modified scaffold-Sa-L2	AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA with modified scaffold sequence	Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
Vector	Viral Vector	AAVrh8-ZsGreen-Cre	AAV backbone with a bi-directional promoter driving zsGreen and Cre	Experiments AAV Tropism project
Vector	Viral Vector	demo VV03-Cre	DEMO viral vector for demo purpose	Experiments MOCK VIRUS TROPISM STUDY For Toolkit demonstration purposes only
Vector	Viral Vector	demo VV04-Cre	DEMO viral vector for demo purpose	Experiments MOCK VIRUS TROPISM STUDY For Toolkit demonstration purposes only
Vector	Expression Plasmid	pPP394	Plasmid containing Homo sapiens codon optimized CasΦ-1 and spacer for editing in human cells.	Experiments Testing newly discovered Biggie Phage editors in human cells
Vector	Viral Vector	AAV7-ZsGreen-Cre	AAV backbone with a bi-directional promoter driving zsGreen and Cre	Experiments AAV Tropism project
Vector	Viral Vector	AAV9-Ai9-sgRNA1 + sgRNA2	AAV serotype 9 delivering u6 promoter driving sgRNA 1 + sgRNA2 targeting the Ai9 locus	Experiments Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 cas9 to sgRNA ratio (CMV promoter) Comparing CRISPR/Cas9 gene editing efficiencies between AAV9 and AAVcc47 in Ai9 mice with a 1:3 Cas9 to sgRNA ratio (CMV promoter)
Vector	Viral Vector	AAV9-CMV-Cre	AAV serotype 9 delivering CMV Cre Recombinase	Experiments Cre Recombinase dose escalation study in Ai9 mice
Vector	Viral Vector	AAV9_pTR_self comp 2xU6-Ai9 guides	AAV serotype 9 delivering u6 promoter driving sgRNA 1 + sgRNA2 (self complementray vector) targeting Ai9 transgene	Experiments Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 Cas9 to sgRNA ratio (CMV promoter) and self complementary sgRNA vector.
Vector	Viral Vector	AAVcc47-mCherry	AAV2/9 self complementary vector with capsid variant cc47 expressing Mcherry driven by CBh promoter	Experiments Testing virus region 4 (VR4) mutant cross-species compatible Adeno Associated Viruses (ccAAVs) in mice.
Vector	Viral Vector	AAV-CMV-SaCas9-U6-gRNA-LoxP-Sa-L3	AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA	Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
Vector	Viral Vector	AAV-CMV-SaCas9-U6-modified scaffold-Sa-LoxP1	AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA with modified scaffold sequence	Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
Vector	Viral Vector	AAV-CMV-SaCas9-U6-modified scaffold-Sa-R1	AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA with modified scaffold sequence	Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
Vector	Viral Vector	AAV-CMV-SaCas9-U6-modified scaffold-Sa-R2	AAV shuttle vector with CMV promoter driven SaCas9 and U6 promoter driven gRNA with modified scaffold sequence	Experiments Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro
Vector	Viral Vector	BI28:AAV-GFAP-NLS-GFP-WPRE-synpA-L1-R2	Novel engineered AAV BI28 variant expressing NLS-GFP driven by the glial fibrillary acidic protein (GFAP) promoter and dual sgRNAs with modified scaffolds	Experiments Testing gRNA sequence and gRNA scaffold modified in Ai9 mice. Second site validation of Deverman delivery platform using engineered AAVs to deliver CRSIPR/Cas9 to mouse brain
Vector	Viral Vector	demo VV01-Cre	DEMO viral vector for demo purpose	Experiments MOCK VIRUS TROPISM STUDY For Toolkit demonstration purposes only
Vector	Viral Vector	H509 AAVsc-u6-sgAI9L-U6-AI9R-U1A-EGFP (1)	AAV2/5 expressing SpyCas9. AAV2/5 expressing two sgRNAs under U6 promoter and eGFP	Experiments Testing AAV5 for activation of tdTomato in mouse airway Testing AAV5 for activation of tdTomato in mouse airway club and ciliated cells
Vector	Viral Vector	pAAV.pU1a-SpCas9	Expresses codon-optimized SpCas9 in mammalian cells. HA-SV40NLS-SpCas9-SV40NLS	Experiments Testing AAV5 for activation of tdTomato in HEK293T cells
Vector	Expression Plasmid	pPP441	Plasmid containing Homo sapiens codon optimized CasΦ-2 and spacer for editing in human cells.	Experiments Testing newly discovered Biggie Phage editors in human cells

Contact SCGE

62 results in Vectors

AAV6-ZsGreen-Cre - Vector - [In Vivo] [AAV tropism] [Mouse]

AAV9-Ai9-sgRNA2-CB-SaCas9 - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse]

AAVcc47-Ai9-sgRNA1 + sgRNA2 - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse]

AAVcc84-GFP - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse]

AAV-CMV-SaCas9-U6-gRNA-LoxP-Sa-L1 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse]

AAV-CMV-SaCas9-U6-gRNA-LoxP-Sa-L2 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse]

AAVrh10-ZsGreen-Cre - Vector - [In Vivo] [AAV tropism] [Mouse]

AAVrh74-ZsGreen-Cre - Vector - [In Vivo] [AAV tropism] [Mouse]

demo VV02-Cre - Vector - [In Vivo] [DCC] [Mouse]

scAAV5-Cre-GFP - Vector - [In Vivo] [Small Animal Testing Center (SATC)] [Mouse]

AAV9-GFP - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse]

AAV9-mCherry - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse]

AAVcc47-CMV-SaCas9 - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse]

AAVcc47-SaCas9-Ai9 - Vector - [In Vivo] [Small Animal Testing Center (SATC)] [Mouse]

AAV-CMV-SaCas9-U6-modified scaffold-Sa-L1 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse]

AAV-CMV-SaCas9-U6-modified scaffold-Sa-LoxP2 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse]

AAV-Pcsk9 - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse]

pH509 AAVsc-u6-sgAI9L-U6-AI9R-U1A-EGFP (1) - Vector - [In Vitro] [Delivery Systems Initiative] [Human]

AAV3b-ZsGreen-Cre - Vector - [In Vivo] [AAV tropism] [Mouse]

AAV5-ZsGreen-Cre - Vector - [In Vivo] [AAV tropism] [Mouse]

AAV8-ZsGreen-Cre - Vector - [In Vivo] [AAV tropism] [Mouse]

AAV9-Ai9-sgRNA1-CB-SaCas9 - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse]

AAVcc47-Ai9-sgRNA2-CB-SaCas9 - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse]

AAVcc47-Cre - Vector - [In Vivo] [Small Animal Testing Center (SATC)] [Mouse]

AAVcc81-GFP - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse]

AAV-CMV-SaCas9-U6-gRNA-LoxP-Sa-LoxP1 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse]

AAV-CMV-SaCas9-U6-gRNA-LoxP-Sa-LoxP2 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse]

AAV-CMV-SaCas9-U6-modified scaffold-Sa-L3 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse]

AAV.pU1a-SpCas9 - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse]

BI28:AAV-GFAP-SaCas9-WPRE3-pA - Vector - [In Vivo] [Small Animal Testing Center (SATC), Delivery Systems Initiative] [Mouse]

demo VV05-Cre - Vector - [In Vivo] [DCC] [Mouse]

pPP444 - Vector - [In Vitro] [Genome Editors] [Human]

ssAAV5-sgA+sgB-U1A.GFP - Vector - [In Vivo] [Small Animal Testing Center (SATC)] [Mouse]

ssAAV5-sgB.saCas9 - Vector - [In Vivo] [Small Animal Testing Center (SATC)] [Mouse]

ssAAV5-spCas9 - Vector - [In Vivo] [Small Animal Testing Center (SATC)] [Mouse]

AAV4-ZsGreen-Cre - Vector - [In Vivo] [AAV tropism] [Mouse]

AAV9-CMV-SaCas9 - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse]

AAV9-ZsGreen-Cre - Vector - [In Vivo] [AAV tropism] [Mouse]

AAVcc47-Ai9-sgRNA1-CB-SaCas9 - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse]

AAVcc47-CMV-Cre - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse]

AAVcc47_pTR_self comp 2xU6-Ai9 guides - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse]

AAV-CMV-SaCas9-U6-gRNA-LoxP-Sa-R1 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse]

AAV-CMV-SaCas9-U6-gRNA-LoxP-Sa-R2 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse]

AAV-CMV-SaCas9-U6-modified scaffold-Sa-L2 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse]

AAVrh8-ZsGreen-Cre - Vector - [In Vivo] [AAV tropism] [Mouse]

demo VV03-Cre - Vector - [In Vivo] [DCC] [Mouse]

demo VV04-Cre - Vector - [In Vivo] [DCC] [Mouse]

pPP394 - Vector - [In Vitro] [Genome Editors] [Human]

AAV7-ZsGreen-Cre - Vector - [In Vivo] [AAV tropism] [Mouse]

AAV9-Ai9-sgRNA1 + sgRNA2 - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse]

AAV9-CMV-Cre - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse]

AAV9_pTR_self comp 2xU6-Ai9 guides - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse]

AAVcc47-mCherry - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse]

AAV-CMV-SaCas9-U6-gRNA-LoxP-Sa-L3 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse]

AAV-CMV-SaCas9-U6-modified scaffold-Sa-LoxP1 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse]

AAV-CMV-SaCas9-U6-modified scaffold-Sa-R1 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse]

AAV-CMV-SaCas9-U6-modified scaffold-Sa-R2 - Vector - [In Vitro] [Delivery Systems Initiative] [Mouse]

BI28:AAV-GFAP-NLS-GFP-WPRE-synpA-L1-R2 - Vector - [In Vivo] [Small Animal Testing Center (SATC), Delivery Systems Initiative] [Mouse]

demo VV01-Cre - Vector - [In Vivo] [DCC] [Mouse]

H509 AAVsc-u6-sgAI9L-U6-AI9R-U1A-EGFP (1) - Vector - [In Vivo] [Delivery Systems Initiative] [Mouse]

pAAV.pU1a-SpCas9 - Vector - [In Vitro] [Delivery Systems Initiative] [Human]

pPP441 - Vector - [In Vitro] [Genome Editors] [Human]

62 results in Vectors