35 results in Genome Editors

Alt-R® S.p. Cas9 Nuclease V3

Genome Editor  - [In Vivo, In Vitro] [Small Animal Testing Center (SATC), Delivery Systems Initiative] [Mouse]
Matched Fields: category : Genome Editor
Recombinant S. pyogenes Cas9 nuclease, purified from an E. coli strain expressing the nuclease. Contains nuclear localization sequence (NLS) and C-terminal 6-His tag. Provided in solution at 10 µg/µL. 100 µg of Cas9 nuclease = 610 pmol.
Show Experiments (9)

Shuttle peptides enable in vivo gene editing with Cas9 and Cas12a RNP in mouse airway epithelia
Validating Traffic Light Reporter 2 (TLR2) Mouse Model in Heterozygous Blastocysts using SpCas9
Validating Traffic Light Reporter 2 (TLR2) Mouse Model in Homozygous Blastocysts using SpCas9
Validating Gene Editing Reporter 12 (GER12) Mouse Model in Heterozygous Blastocysts
Validating Traffic Light Reporter 7 (TLR7) Mouse Model for NHEJ in Heterozygous Blastocysts
Validating Gene Editing Reporter 14 (GER14) Mouse Model in Heterozygous Blastocysts
Validating Gene Editing Reporter 18 (GER18) Mouse Model in Heterozygous Blastocysts
Validating Gene Editing Reporter 19 (GER19) Mouse Model in Heterozygous Blastocysts
Validating Traffic Light Reporter 7 (TLR7) Mouse Model for HDR in Heterozygous Blastocysts

AsCas12a (IDT and Feldan Therapeutics)

Genome Editor  - [In Vivo] [Delivery Systems Initiative] [Mouse]
Matched Fields: category : Genome Editor

CleanCap® Cre mRNA

Genome Editor  - [In Vitro] [Small Animal Testing Center (SATC)] [Mouse]
Matched Fields: category : Genome Editor
CleanCap® NLS-Cre Recombinase mRNA (5-methoxyuridine)

SaCas9

Genome Editor  - [In Vivo] [Small Animal Testing Center (SATC)] [Mouse]
Matched Fields: category : Genome Editor

SaCas9 (AAV-SaCas9)

Genome Editor  - [In Vitro] [Biological Effects Initiative] [Human]
Matched Fields: category : Genome Editor
SaCas9 delivered by AAV-SaCas9 vector

sNLS-SpCas9-sNLS

Genome Editor  - [In Vivo, In Vitro] [Small Animal Testing Center (SATC), Collaborative Opportunity Fund, Delivery Systems Initiative] [Human, Mouse]
Matched Fields: category : Genome Editor
SpCas9 with N- and C-terminal SV40 NLS

SpCas9

Genome Editor  - [In Vivo, In Vitro] [Delivery Systems Initiative, Biological Systems] [Human, Mouse]
Matched Fields: category : Genome Editor
HA-SV40NLS-SpCas9-SV40NLS

SpyCas9-3xNLS

Genome Editor  - [In Vivo, In Vitro] [Delivery Systems Initiative] [Human, Mouse]
Matched Fields: category : Genome Editor
SpyCas9-3xNLS is type II-A Cas9 from Streptococcus pyogenes strain SF370. It was expressed from pMCSG7 bacterial expressing vector and purified from Escherichia coli Rosetta DE3 strain. SpyCas9 fused to 3 NLS: C-Myc-like NLS at the N-terminal SV40 NLS and Nucleoplasmin NLS at the C-terminal

ABE8e-Cas12a

Genome Editor  - [In Vitro] [Collaborative Opportunity Fund] [Rhesus macaque]
Matched Fields: category : Genome Editor
A-to-G base editor

CasΦ-3

Genome Editor  - [In Vitro] [Genome Editors] [Human]
Matched Fields: category : Genome Editor
Compact editor of the Cas12j family identified in biggie phage from metagenomic assemblies

CleanCap® Cas9 mRNA (5moU)

Genome Editor  - [In Vivo] [Small Animal Testing Center (SATC)] [Mouse]
Matched Fields: category : Genome Editor
SpCas9 mRNA with 2 NLS signals, HA tag and capped using CleanCap. It is polyadenylated, substituted with a modified uridine and optimized for mammalian systems. It mimics a fully processed mature mRNA.

SpyCas9-ProteinG-3xNLS

Genome Editor  - [In Vitro] [Collaborative Opportunity Fund] [Human]
Matched Fields: category : Genome Editor
Engineered SpCas9 with protein G to bind immunoglobulins which binds to Fc subunit of antibodies. Has three different nuclear localization signals (NLS) located at both, the N-term and C-term.

ABE7.10

Genome Editor  - [In Vitro] [Small Animal Testing Center (SATC)] [Mouse]
Matched Fields: category : Genome Editor
SV40NLS-ABE7.10

CasΦ-2

Genome Editor  - [In Vitro] [Genome Editors] [Human]
Matched Fields: category : Genome Editor
Compact editor of the Cas12j family identified in biggie phage from metagenomic assemblies

EnGen® Sau Cas9

Genome Editor  - [In Vitro] [Small Animal Testing Center (SATC)] [Mouse]
Matched Fields: category : Genome Editor

GFP-NLS

Genome Editor  - [In Vivo] [Delivery Systems Initiative] [Mouse]
Matched Fields: category : Genome Editor
Nuclear targeted GFP

SauCas9

Genome Editor  - [In Vivo] [Small Animal Testing Center (SATC)] [Mouse]
Matched Fields: category : Genome Editor

sNLS-SaCas9-sNLS Nuclease

Genome Editor  - [In Vitro] [Small Animal Testing Center (SATC)] [Mouse]
Matched Fields: category : Genome Editor
SaCas9 with N- and C-terminal SV40 NLS

Alt-R A.s. Cas12a (Cpf1) V3

Genome Editor  - [In Vitro] [Small Animal Testing Center (SATC)] [Mouse]
Matched Fields: category : Genome Editor
Recombinant Acidaminococcus sp. BV3L6 (A.s.) nuclease, purified from an E. coli strain expressing Cas12a. Contains nuclear localization sequence (NLS) and C-terminal 6-His tag. Provided in solution at 10 µg/µL. 100 µg of Cas12a nuclease = 633 pmol.

CasΦ-1

Genome Editor  - [In Vitro] [Genome Editors] [Human]
Matched Fields: category : Genome Editor
Compact editor of the Cas12j family identified in biggie phage from metagenomic assemblies

SpyCas9-3xNLS

Genome Editor  - [In Vivo] [Delivery Systems Initiative] [Mouse]
Matched Fields: category : Genome Editor
SpyCas9-3xNLS is type II-A Cas9 from Streptococcus pyogenes strain SF370. It was expressed from pMCSG7 bacterial expressing vector and purified from Escherichia coli Rosetta DE3 strain. SpyCas9 fused to 3 NLS: C-Myc-like NLS at the N-terminal SV40 NLS and Nucleoplasmin NLS at the C-terminal
Show Experiments (5)

Delivery of unmodified, phosphorothioate (PS)-stabilized crRNA with chemically modified, PS-stabilized tracrRNA using the S10 shuttle peptide to activate the mTmG reporter in mouse brain
Delivery of unmodified, phosphorothioate (PS)-stabilized crRNA with chemically modified, extended PS-stabilized tracrRNA to activate the mTmG reporter in mouse brain
Delivery of chemically modified, phosphorothioate (PS)-stabilized crRNA with chemically modified, PS-stabilized tracrRNA to activate the mTmG reporter in mouse brain
Delivery of chemically modified, phosphorothioate (PS)-stabilized crRNA with chemically modified, extended PS-stabilized tracrRNA to activate the mTmG reporter in mouse brain
Delivery of RNP containing chemically modified crRNA C20 with chemically modified tracrRNA T2-PS to determine the RNP distribution in TLR-MCV mouse brain

ABE8e

Genome Editor  - [In Vitro] [Collaborative Opportunity Fund] [Mouse, Rhesus macaque]
Matched Fields: category : Genome Editor
Tad8e deaminase fused to a nickase (D10A) spCas9

ABE8e

Genome Editor  - [In Vivo] [Small Animal Testing Center (SATC)] [Mouse]
Matched Fields: category : Genome Editor
Catalytically impaired Cas fused to TadA deaminase

CleanCap® Cas9

Genome Editor  - [In Vivo, In Vitro] [Delivery Systems Initiative] [Mouse]
Matched Fields: category : Genome Editor
SpCas9 mRNA with 2 NLS signals, HA tag and capped using CleanCap. It is polyadenylated, substituted with a modified uridine and optimized for mammalian systems. It mimics a fully processed mature mRNA.

CleanCap® Fluc

Genome Editor  - [In Vivo] [Delivery Systems Initiative] [Mouse]
Matched Fields: category : Genome Editor
Firefly luciferase mRNA capped using CleanCap. It is polyadenylated, modified with 5-methoxyuridine and optimized for mammalian systems. It mimics a fully processed mature mRNA.

Cre recombinase

Genome Editor  - [In Vitro] [Delivery Systems Initiative] [Human]
Matched Fields: category : Genome Editor
Cre recombinase delivered by plasmid (see vector details)

SaCas9

Genome Editor  - [In Vivo] [Delivery Systems Initiative] [Mouse]
Matched Fields: category : Genome Editor

TadA-8e V106W

Genome Editor  - [In Vivo] [Delivery Systems Initiative] [Mouse]
Matched Fields: category : Genome Editor
Catalytically impaired Cas fused to evolved TadA deaminase (TadA-8e V106W)

35 results in Genome Editors

Type Subtype Name Description Source View Associated..
Cas Nuclease Cas9 Alt-R® S.p. Cas9 Nuclease V3 Recombinant S. pyogenes Cas9 nuclease, purified from an E. coli strain expressing the nuclease. Contains nuclear localization sequence (NLS) and C-terminal 6-His tag. Provided in solution at 10 µg/µL. 100 µg of Cas9 nuclease = 610 pmol. Integrated DNA Technologies
Show Experiments (9)

Shuttle peptides enable in vivo gene editing with Cas9 and Cas12a RNP in mouse airway epithelia
Validating Traffic Light Reporter 2 (TLR2) Mouse Model in Heterozygous Blastocysts using SpCas9
Validating Traffic Light Reporter 2 (TLR2) Mouse Model in Homozygous Blastocysts using SpCas9
Validating Gene Editing Reporter 12 (GER12) Mouse Model in Heterozygous Blastocysts
Validating Traffic Light Reporter 7 (TLR7) Mouse Model for NHEJ in Heterozygous Blastocysts
Validating Gene Editing Reporter 14 (GER14) Mouse Model in Heterozygous Blastocysts
Validating Gene Editing Reporter 18 (GER18) Mouse Model in Heterozygous Blastocysts
Validating Gene Editing Reporter 19 (GER19) Mouse Model in Heterozygous Blastocysts
Validating Traffic Light Reporter 7 (TLR7) Mouse Model for HDR in Heterozygous Blastocysts

Cas Nuclease Cas12a (Cpf1) AsCas12a (Feldan Therapeutics) Feldan Therapeutics
Cas Nuclease Cas12a (Cpf1) AsCas12a (IDT and Feldan Therapeutics) IDT and Feldan Therapeutics
Cre Recombinase Tyrosine recombinase CleanCap® Cre mRNA CleanCap® NLS-Cre Recombinase mRNA (5-methoxyuridine) TriLink
Cas Nuclease Cas9 SaCas9 Vector Encoded (ssaav5-sga+sgb-u1a.gfp)
Cas Nuclease Cas9 SaCas9
Cas Cas9 SaCas9 (AAV-SaCas9) SaCas9 delivered by AAV-SaCas9 vector VectorBuilder
Cas Nuclease Cas9 SaCas9-Lagor William Lagor, Baylor College Of Medicine
Cas Nuclease Cas9 sNLS-SpCas9-sNLS SpCas9 with N- and C-terminal SV40 NLS Aldevron 9212-5MG
Cas Nuclease Cas9 SpCas9 IDT
Cas Nuclease Cas9 SpCas9 HA-SV40NLS-SpCas9-SV40NLS Vector Encoded
Cas Nuclease Cas9 SpyCas9-3xNLS SpyCas9-3xNLS is type II-A Cas9 from Streptococcus pyogenes strain SF370. It was expressed from pMCSG7 bacterial expressing vector and purified from Escherichia coli Rosetta DE3 strain. SpyCas9 fused to 3 NLS: C-Myc-like NLS at the N-terminal SV40 NLS and Nucleoplasmin NLS at the C-terminal Sontheimer lab
Cas Cas12a ABE8e-Cas12a A-to-G base editor Liu lab
Cas Cas9 ABE8e-Cas9 A-to-G base editor Feldan Therapeutics
Cas Nuclease Cas12j CasΦ-3 Compact editor of the Cas12j family identified in biggie phage from metagenomic assemblies Jennifer Doudna Lab
Cas Nuclease Cas9 CleanCap® Cas9 mRNA (5moU) SpCas9 mRNA with 2 NLS signals, HA tag and capped using CleanCap. It is polyadenylated, substituted with a modified uridine and optimized for mammalian systems. It mimics a fully processed mature mRNA. Trilink Biotechnologies
Cas Cas9 SpyCas9-ProteinG-3xNLS Engineered SpCas9 with protein G to bind immunoglobulins which binds to Fc subunit of antibodies. Has three different nuclear localization signals (NLS) located at both, the N-term and C-term. Ross Wilson Lab
Base editor Adenine base editor ABE7.10 SV40NLS-ABE7.10 Aldevron / Mark Osborn Lab
Cas Nuclease Cas12j CasΦ-2 Compact editor of the Cas12j family identified in biggie phage from metagenomic assemblies Jennifer Doudna Lab
Cas Cas9 EnGen® Sau Cas9 NEB
Reporter Fluorescent protein GFP-NLS Nuclear targeted GFP Expressed From (Escherichia coli BL21DE3)
Cas Nuclease Cas9 SauCas9
Cas Cas9 sNLS-SaCas9-sNLS Nuclease SaCas9 with N- and C-terminal SV40 NLS Aldevron
Cas Nuclease Cas9 SpCas9 (Feldan Therapeutics) Feldan Therapeutics
Cas Cas12a (Cpf1) V3 Alt-R A.s. Cas12a (Cpf1) V3 Recombinant Acidaminococcus sp. BV3L6 (A.s.) nuclease, purified from an E. coli strain expressing Cas12a. Contains nuclear localization sequence (NLS) and C-terminal 6-His tag. Provided in solution at 10 µg/µL. 100 µg of Cas12a nuclease = 633 pmol. IDT
Cas Nuclease Cas12j CasΦ-1 Compact editor of the Cas12j family identified in biggie phage from metagenomic assemblies Jennifer Doudna Lab
Recombinase Tyrosine recombinase Cre recombinase Cre recombinase delivered by AAV (see vector details)
Cas Nuclease Cas9 SpyCas9-3xNLS SpyCas9-3xNLS is type II-A Cas9 from Streptococcus pyogenes strain SF370. It was expressed from pMCSG7 bacterial expressing vector and purified from Escherichia coli Rosetta DE3 strain. SpyCas9 fused to 3 NLS: C-Myc-like NLS at the N-terminal SV40 NLS and Nucleoplasmin NLS at the C-terminal Sontheimer lab
Show Experiments (5)

Delivery of unmodified, phosphorothioate (PS)-stabilized crRNA with chemically modified, PS-stabilized tracrRNA using the S10 shuttle peptide to activate the mTmG reporter in mouse brain
Delivery of unmodified, phosphorothioate (PS)-stabilized crRNA with chemically modified, extended PS-stabilized tracrRNA to activate the mTmG reporter in mouse brain
Delivery of chemically modified, phosphorothioate (PS)-stabilized crRNA with chemically modified, PS-stabilized tracrRNA to activate the mTmG reporter in mouse brain
Delivery of chemically modified, phosphorothioate (PS)-stabilized crRNA with chemically modified, extended PS-stabilized tracrRNA to activate the mTmG reporter in mouse brain
Delivery of RNP containing chemically modified crRNA C20 with chemically modified tracrRNA T2-PS to determine the RNP distribution in TLR-MCV mouse brain

Base editor Adenine base editor ABE8e Tad8e deaminase fused to a nickase (D10A) spCas9 David Liu Lab
Adenine Base Editor ABE8e Catalytically impaired Cas fused to TadA deaminase Liu Lab
Cas Nuclease Cas9 CleanCap® Cas9 SpCas9 mRNA with 2 NLS signals, HA tag and capped using CleanCap. It is polyadenylated, substituted with a modified uridine and optimized for mammalian systems. It mimics a fully processed mature mRNA. Trilink Biotechnologies
Reporter Bioluminescent CleanCap® Fluc Firefly luciferase mRNA capped using CleanCap. It is polyadenylated, modified with 5-methoxyuridine and optimized for mammalian systems. It mimics a fully processed mature mRNA. Trilink Biotechnologies
Recombinase Tyrosine recombinase Cre recombinase Cre recombinase delivered by plasmid (see vector details)
Cas Nuclease Cas9 SaCas9 Leong Lab
Base Editor (SpCas9) Adenine base editor TadA-8e V106W Catalytically impaired Cas fused to evolved TadA deaminase (TadA-8e V106W) Chaikof Lab