Genome Editors

List View
Table View

22 results in Genome Editors

CleanCap® Cas9 - Genome Editor Matched on: SpCas9 mRNA with 2 NLS signals, HA tag and capped using CleanCap. It is polyadenylated, substituted with a modified uridine and optimized for mammalian systems. It mimics a fully processed mature mRNA. View Associated: Testing new LNPs (lipid nanoparticles) for delivery of Cas9 mRNA/sgRNA in primary fibroblast cells from adult Ai14 mouse cochlea Testing new LNPs (lipid nanoparticles) for delivery of Cas9 mRNA/sgRNA in adult mouse cochlea
Alt-R® S.p. Cas9 Nuclease V3 - Genome Editor Matched on: View Associated:
CasΦ-1 - Genome Editor Matched on: Compact editor of the Cas12j family identified in biggie phage from metagenomic assemblies View Associated:
Cre recombinase - Genome Editor Matched on: Cre recombinase delivered by AAVcc47-Cre viral vector View Associated:
GFP-NLS - Genome Editor Matched on: Nuclear targeted GFP View Associated:
SaCas9 - Genome Editor Matched on: View Associated: Novel AAVs Engineered for Efficient and Noninvasive Cross-Species Gene Editing Throughout the Central Nervous System BCM-Rice Resource for the Analysis of Somatic Gene Editing in Mice - Deverman Validation (Deverman, Benjamin) Testing gRNA sequence and gRNA scaffold modified in Ai9 mice. Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro Second site validation of Deverman delivery platform using engineered AAVs to deliver CRSIPR/Cas9 to mouse brain
SpCas9 (Feldan Therapeutics) - Genome Editor Matched on: View Associated: Delivery of CRISPR Ribonucleoproteins to Airway Epithelia Using Novel Amphiphilic Peptides Delivery of CRISPR Ribonucleoproteins to Airway Epithelia Using Novel Amphiphilic Peptides Peptide Shuttle optimization to deliver Cas9 RNP to human airway epithelia cells Gene editing in vitro by various peptide variants delivering Cas RNPs to primary Human airway epithelia cells.
SpyCas9-3xNLS - Genome Editor Matched on: SpyCas9-3xNLS is type II-A Cas9 from Streptococcus pyogenes strain SF370. It was expressed from pMCSG7 bacterial expressing vector and purified from Escherichia coli Rosetta DE3 strain. SpyCas9 fused to 3 NLS: C-Myc-like NLS at the N-terminal SV40 NLS and Nucleoplasmin NLS at the C-terminal View Associated: Delivery of chemically modified, phosphorothioate (PS)-stabilized crRNA with chemically modified, PS-stabilized tracrRNA to activate the mTmG reporter in mouse brain Delivery of chemically modified, phosphorothioate (PS)-stabilized crRNA with chemically modified, extended PS-stabilized tracrRNA to activate the mTmG reporter in mouse brain Delivery of RNP containing chemically modified crRNA C20 with chemically modified tracrRNA T2-PS to determine the RNP distribution in TLR-MCV mouse brain Delivery of unmodified, phosphorothioate (PS)-stabilized crRNA with chemically modified, PS-stabilized tracrRNA using the S10 shuttle peptide to activate the mTmG reporter in mouse brain Delivery of unmodified, phosphorothioate (PS)-stabilized crRNA with chemically modified, extended PS-stabilized tracrRNA to activate the mTmG reporter in mouse brain
CasΦ-2 - Genome Editor Matched on: Compact editor of the Cas12j family identified in biggie phage from metagenomic assemblies View Associated:
Cre recombinase - Genome Editor Matched on: Cre recombinase delivered by pAAV-EF1a-Cre plasmid View Associated:
SpCas9 - Genome Editor Matched on: View Associated:
SpyCas9-3xNLS - Genome Editor Matched on: SpyCas9-3xNLS is type II-A Cas9 from Streptococcus pyogenes strain SF370. It was expressed from pMCSG7 bacterial expressing vector and purified from Escherichia coli Rosetta DE3 strain. SpyCas9 fused to 3 NLS: C-Myc-like NLS at the N-terminal SV40 NLS and Nucleoplasmin NLS at the C-terminal View Associated: Enhancing CRISPR Gene Editing in Somatic Tissues by Chemical Modification of Guides and Donors Enhancing CRISPR Gene Editing in Somatic Tissues by Chemical Modification of Guides and Donors Testing newly chemically modified crRNA and tracrRNA in mTmG mouse embryonic fibroblasts Testing newly chemically modified crRNA and tracrRNA to activate the TLR1 reporter in human cells Testing newly chemically modified crRNA and tracrRNA in mouse Hepa 1-6 cells Testing newly chemically modified crRNA and tracrRNA in mouse Neuro 2A cells Testing preparation for validation at The Jackson Laboratory Small Animal Testing Center Testing newly chemically modified crRNA and tracrRNA to activate the TLR reporter in human cells
AsCas12a (Feldan Therapeutics) - Genome Editor Matched on: View Associated: Delivery of CRISPR Ribonucleoproteins to Airway Epithelia Using Novel Amphiphilic Peptides Delivery of CRISPR Ribonucleoproteins to Airway Epithelia Using Novel Amphiphilic Peptides Gene editing in vitro by various peptide variants delivering Cas RNPs to primary Human airway epithelia cells. Peptide Shuttle optimization to deliver Cas12a RNP to human airway epithelia cells Gene editing in vitro by various peptide variants delivering Cas12a in NK cells.
AsCas12a (IDT and Feldan Therapeutics) - Genome Editor Matched on: View Associated:
CasΦ-3 - Genome Editor Matched on: Compact editor of the Cas12j family identified in biggie phage from metagenomic assemblies View Associated:
CleanCap® Cas9 mRNA (5moU) - Genome Editor Matched on: SpCas9 mRNA with 2 NLS signals, HA tag and capped using CleanCap. It is polyadenylated, substituted with a modified uridine and optimized for mammalian systems. It mimics a fully processed mature mRNA. View Associated: Repeat experiment of second site validation of Chen delivery platform using LNPs to deliver CRISPR/Cas9 to mouse inner ear Second site validation of Chen delivery platform using LNPs to deliver CRISPR/Cas9 to mouse inner ear
CleanCap® Fluc - Genome Editor Matched on: Firefly luciferase mRNA capped using CleanCap. It is polyadenylated, modified with 5-methoxyuridine and optimized for mammalian systems. It mimics a fully processed mature mRNA. View Associated:
Cre recombinase - Genome Editor Matched on: Cre recombinase delivered by scAAV5-Cre-GFP plasmid View Associated:
SaCas9-Lagor - Genome Editor Matched on: View Associated: Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 Cas9 to sgRNA ratio (CB promoter) Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 cas9 to sgRNA ratio (CMV promoter) Comparing CRISPR/Cas9 gene editing efficiencies between AAV9 and AAVcc47 in Ai9 mice with a 1:3 Cas9 to sgRNA ratio (CMV promoter) Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 Cas9 to sgRNA ratio (CMV promoter) and self complementary sgRNA vector.
SauCas9 - Genome Editor Matched on: View Associated:
sNLS-SpCas9-sNLS - Genome Editor Matched on: SpCas9 with N- and C-terminal SV40 NLS View Associated: The Jackson Laboratory Gene Editing Testing Center - Gong Validation (Gong, Shaoqin) Enabling Nanoplatforms for Targeted In Vivo Delivery of CRISPR/Cas9 Riboncleoproteins in the Brain Second site validation of Gong delivery platform using RNP-loaded nanocages to deliver CRISPR/Cas9 to mouse brain Enabling Nanoplatforms for Targeted in vivo Delivery of CRISPR/Cas9 Ribonucleoproteins in the Brain.
SpCas9 - Genome Editor Matched on: HA-SV40NLS-SpCas9-SV40NLS View Associated: Develop Combinatorial Non-Viral and Viral CRISPR Delivery for Lung Diseases A Novel Human T-Cell Platform to Define Biological Effects of Genome Editing Testing AAV5 for activation of tdTomato in HEK293T cells Testing AAV5 for activation of tdTomato in mouse airway A novel human T cell platform to define biological adverse effects of genome editing

22 results in Genome Editors

Category	Type	Name	Description	View Associated..
Genome Editor	Cas Nuclease	CleanCap® Cas9	SpCas9 mRNA with 2 NLS signals, HA tag and capped using CleanCap. It is polyadenylated, substituted with a modified uridine and optimized for mammalian systems. It mimics a fully processed mature mRNA.	Testing new LNPs (lipid nanoparticles) for delivery of Cas9 mRNA/sgRNA in primary fibroblast cells from adult Ai14 mouse cochlea Testing new LNPs (lipid nanoparticles) for delivery of Cas9 mRNA/sgRNA in adult mouse cochlea
Genome Editor	Cas Nuclease	Alt-R® S.p. Cas9 Nuclease V3
Genome Editor	Cas Nuclease	CasΦ-1	Compact editor of the Cas12j family identified in biggie phage from metagenomic assemblies
Genome Editor	Recombinase	Cre recombinase	Cre recombinase delivered by AAVcc47-Cre viral vector
Genome Editor	Reporter	GFP-NLS	Nuclear targeted GFP
Genome Editor	Cas Nuclease	SaCas9		Novel AAVs Engineered for Efficient and Noninvasive Cross-Species Gene Editing Throughout the Central Nervous System BCM-Rice Resource for the Analysis of Somatic Gene Editing in Mice - Deverman Validation (Deverman, Benjamin) Testing gRNA sequence and gRNA scaffold modified in Ai9 mice. Selection of gRNA sequences and gRNA scaffold modification lead to improved editing of the Ai9 locus in vitro Second site validation of Deverman delivery platform using engineered AAVs to deliver CRSIPR/Cas9 to mouse brain
Genome Editor	Cas Nuclease	SpCas9 (Feldan Therapeutics)		Delivery of CRISPR Ribonucleoproteins to Airway Epithelia Using Novel Amphiphilic Peptides Delivery of CRISPR Ribonucleoproteins to Airway Epithelia Using Novel Amphiphilic Peptides Peptide Shuttle optimization to deliver Cas9 RNP to human airway epithelia cells Gene editing in vitro by various peptide variants delivering Cas RNPs to primary Human airway epithelia cells.
Genome Editor	Cas Nuclease	SpyCas9-3xNLS	SpyCas9-3xNLS is type II-A Cas9 from Streptococcus pyogenes strain SF370. It was expressed from pMCSG7 bacterial expressing vector and purified from Escherichia coli Rosetta DE3 strain. SpyCas9 fused to 3 NLS: C-Myc-like NLS at the N-terminal SV40 NLS and Nucleoplasmin NLS at the C-terminal	Delivery of chemically modified, phosphorothioate (PS)-stabilized crRNA with chemically modified, PS-stabilized tracrRNA to activate the mTmG reporter in mouse brain Delivery of chemically modified, phosphorothioate (PS)-stabilized crRNA with chemically modified, extended PS-stabilized tracrRNA to activate the mTmG reporter in mouse brain Delivery of RNP containing chemically modified crRNA C20 with chemically modified tracrRNA T2-PS to determine the RNP distribution in TLR-MCV mouse brain Delivery of unmodified, phosphorothioate (PS)-stabilized crRNA with chemically modified, PS-stabilized tracrRNA using the S10 shuttle peptide to activate the mTmG reporter in mouse brain Delivery of unmodified, phosphorothioate (PS)-stabilized crRNA with chemically modified, extended PS-stabilized tracrRNA to activate the mTmG reporter in mouse brain
Genome Editor	Cas Nuclease	CasΦ-2	Compact editor of the Cas12j family identified in biggie phage from metagenomic assemblies
Genome Editor	Recombinase	Cre recombinase	Cre recombinase delivered by pAAV-EF1a-Cre plasmid
Genome Editor	Cas Nuclease	SpCas9
Genome Editor	Cas Nuclease	SpyCas9-3xNLS	SpyCas9-3xNLS is type II-A Cas9 from Streptococcus pyogenes strain SF370. It was expressed from pMCSG7 bacterial expressing vector and purified from Escherichia coli Rosetta DE3 strain. SpyCas9 fused to 3 NLS: C-Myc-like NLS at the N-terminal SV40 NLS and Nucleoplasmin NLS at the C-terminal	Enhancing CRISPR Gene Editing in Somatic Tissues by Chemical Modification of Guides and Donors Enhancing CRISPR Gene Editing in Somatic Tissues by Chemical Modification of Guides and Donors Testing newly chemically modified crRNA and tracrRNA in mTmG mouse embryonic fibroblasts Testing newly chemically modified crRNA and tracrRNA to activate the TLR1 reporter in human cells Testing newly chemically modified crRNA and tracrRNA in mouse Hepa 1-6 cells Testing newly chemically modified crRNA and tracrRNA in mouse Neuro 2A cells Testing preparation for validation at The Jackson Laboratory Small Animal Testing Center Testing newly chemically modified crRNA and tracrRNA to activate the TLR reporter in human cells
Genome Editor	Cas Nuclease	AsCas12a (Feldan Therapeutics)		Delivery of CRISPR Ribonucleoproteins to Airway Epithelia Using Novel Amphiphilic Peptides Delivery of CRISPR Ribonucleoproteins to Airway Epithelia Using Novel Amphiphilic Peptides Gene editing in vitro by various peptide variants delivering Cas RNPs to primary Human airway epithelia cells. Peptide Shuttle optimization to deliver Cas12a RNP to human airway epithelia cells Gene editing in vitro by various peptide variants delivering Cas12a in NK cells.
Genome Editor	Cas Nuclease	AsCas12a (IDT and Feldan Therapeutics)
Genome Editor	Cas Nuclease	CasΦ-3	Compact editor of the Cas12j family identified in biggie phage from metagenomic assemblies
Genome Editor	Cas Nuclease	CleanCap® Cas9 mRNA (5moU)	SpCas9 mRNA with 2 NLS signals, HA tag and capped using CleanCap. It is polyadenylated, substituted with a modified uridine and optimized for mammalian systems. It mimics a fully processed mature mRNA.	Repeat experiment of second site validation of Chen delivery platform using LNPs to deliver CRISPR/Cas9 to mouse inner ear Second site validation of Chen delivery platform using LNPs to deliver CRISPR/Cas9 to mouse inner ear
Genome Editor	Reporter	CleanCap® Fluc	Firefly luciferase mRNA capped using CleanCap. It is polyadenylated, modified with 5-methoxyuridine and optimized for mammalian systems. It mimics a fully processed mature mRNA.
Genome Editor	Recombinase	Cre recombinase	Cre recombinase delivered by scAAV5-Cre-GFP plasmid
Genome Editor	Cas Nuclease	SaCas9-Lagor		Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 Cas9 to sgRNA ratio (CB promoter) Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 cas9 to sgRNA ratio (CMV promoter) Comparing CRISPR/Cas9 gene editing efficiencies between AAV9 and AAVcc47 in Ai9 mice with a 1:3 Cas9 to sgRNA ratio (CMV promoter) Comparing CRISPR/Cas9 gene editing efficencies between AAV9 and AAVcc47 in Ai9 mice with a 1:1 Cas9 to sgRNA ratio (CMV promoter) and self complementary sgRNA vector.
Genome Editor	Cas Nuclease	SauCas9
Genome Editor	Cas Nuclease	sNLS-SpCas9-sNLS	SpCas9 with N- and C-terminal SV40 NLS	The Jackson Laboratory Gene Editing Testing Center - Gong Validation (Gong, Shaoqin) Enabling Nanoplatforms for Targeted In Vivo Delivery of CRISPR/Cas9 Riboncleoproteins in the Brain Second site validation of Gong delivery platform using RNP-loaded nanocages to deliver CRISPR/Cas9 to mouse brain Enabling Nanoplatforms for Targeted in vivo Delivery of CRISPR/Cas9 Ribonucleoproteins in the Brain.
Genome Editor	Cas Nuclease	SpCas9	HA-SV40NLS-SpCas9-SV40NLS	Develop Combinatorial Non-Viral and Viral CRISPR Delivery for Lung Diseases A Novel Human T-Cell Platform to Define Biological Effects of Genome Editing Testing AAV5 for activation of tdTomato in HEK293T cells Testing AAV5 for activation of tdTomato in mouse airway A novel human T cell platform to define biological adverse effects of genome editing

Contact SCGE

22 results in Genome Editors

CleanCap® Cas9 - Genome Editor

Alt-R® S.p. Cas9 Nuclease V3 - Genome Editor

CasΦ-1 - Genome Editor

Cre recombinase - Genome Editor

GFP-NLS - Genome Editor

SaCas9 - Genome Editor

SpCas9 (Feldan Therapeutics) - Genome Editor

SpyCas9-3xNLS - Genome Editor

CasΦ-2 - Genome Editor

Cre recombinase - Genome Editor

SpCas9 - Genome Editor

SpyCas9-3xNLS - Genome Editor

AsCas12a (Feldan Therapeutics) - Genome Editor

AsCas12a (IDT and Feldan Therapeutics) - Genome Editor

CasΦ-3 - Genome Editor

CleanCap® Cas9 mRNA (5moU) - Genome Editor

CleanCap® Fluc - Genome Editor

Cre recombinase - Genome Editor

SaCas9-Lagor - Genome Editor

SauCas9 - Genome Editor

sNLS-SpCas9-sNLS - Genome Editor

SpCas9 - Genome Editor

22 results in Genome Editors