24 results in Model Systems

Ai14 mouse   - Model System [Delivery Systems Initiative] - [In Vivo]
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Ai14 mouse has a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven red fluorescent protein variant (tdTomato) - all inserted into the Gt(ROSA)26Sor locus. The att site flanked neo selection cassette has been removed in this strain.
Ai14 mouse (congenic)   - Model System [Small Animal Testing Center (SATC), Delivery Systems Initiative] - [In Vivo]
Matched on: category -->  Model System
Ai14 mouse has a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven red fluorescent protein variant (tdTomato) - all inserted into the Gt(ROSA)26Sor locus. The att site flanked neo selection cassette has been removed in this strain.
Ai14 mouse primary fibroblasts   - Model System [Delivery Systems Initiative] - [In Vitro]
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Primary fibroblasts from Ai14 mice
Ai9 mouse   - Model System [Small Animal Testing Center (SATC), Delivery Systems Initiative] - [In Vivo]
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Ai9 mouse has a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven red fluorescent protein variant (tdTomato) - all inserted into the Gt(ROSA)26Sor locus.
Ai9 mouse (BCM)   - Model System [Small Animal Testing Center (SATC)] - [In Vivo]
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Ai9 mouse has a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven red fluorescent protein variant (tdTomato) - all inserted into the Gt(ROSA)26Sor locus.
Ai9 mouse immortalized fibroblasts   - Model System [Delivery Systems Initiative] - [In Vitro]
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Immortalized fibroblasts made from Ai9 (B6.Cg-Gt(ROSA)26Sor^tm9(CAG-tdTomato)Hze/J) mice
Ai9-SauSpyCas9 mouse   - Model System [Small Animal Testing Center (SATC)] - [In Vivo]
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Ai9-SauSpyCas9 is a version of Ai9 that has a single guide RNA sites on both sides of the STOP cassette. This is a Cre reporter allele that has a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven red fluorescent protein variant (tdTomato) - all inserted into the Gt(ROSA)26Sor locus. Ai9 mice express robust tdTomato fluorescence following Cre-mediated recombination.
BALB/c mouse   - Model System [Delivery Systems Initiative] - [In Vivo]
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BALB/cJ is a commonly used inbred. Key traits include a susceptibility to developing the demyelinating disease upon infection with Theiler's murine encephalomyelitis virus. The BALB/cJ substrain is susceptible to Listeria, all species of Leishmania, and several species of Trypanosoma, but is resistant to experimental allergic orchitis (EAO).
C57BL/6J mouse   - Model System [Delivery Systems Initiative] - [In Vivo]
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C57BL/6J WT mouse
CD4/CD8 Human Primary T cell   - Model System [Biological Systems] - [In Vitro]
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CD4/CD8 Human Primary T cell
HEK-293-TgEF1a-eGFP-BSD   - Model System [Genome Editors] - [In Vitro]
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HEK293 cells with lentiviral insertion of EF1a promoter driving expression of eGFP and SV40 promoter driving expression of BSD
HEK-293T with Ai9 transient reporter assay   - Model System 
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HEK-293T cells transfected with an Ai9 inducible transgene reporter plasmid used to test gene editing activity by fluorescence
HEK-293T-disrupted_GFP with MCV-mcherry-Puro   - Model System [Delivery Systems Initiative] - [In Vitro]
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HEK293T cells with an integrated reporter for TLR-MCV1 reporter editing
HEK-293T-disrupted_GFP-mcherry-Puro   - Model System [Delivery Systems Initiative] - [In Vitro]
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HEK293T cells with an integrated reporter for TLR1 reporter editing
Hepa1-6   - Model System [Delivery Systems Initiative] - [In Vitro]
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Stable cell line
K562   - Model System 
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Mouse Embryonic Fibroblasts   - Model System [Delivery Systems Initiative] - [In Vitro]
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Primary cell line
NK   - Model System [Delivery Systems Initiative] - [In Vitro]
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Neuro 2A   - Model System [Delivery Systems Initiative] - [In Vitro]
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Stable cell line
TLR-MCV1   - Model System [Delivery Systems Initiative] - [In Vivo]
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TLR-MCV1 transgene knocked into Rosa26 locus
mTmG mouse   - Model System [Delivery Systems Initiative] - [In Vivo]
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ROSAmT/mG is a cell membrane-targeted, two-color fluorescent Cre-reporter allele. Prior to Cre recombination, cell membrane-localized tdTomato (mT) fluorescence expression is widespread in cells/tissues. Cre recombinase expressing cells (and future cell lineages derived from these cells) have cell membrane-localized EGFP (mG) fluorescence expression replacing the red fluorescence
mTmG mouse (congenic)   - Model System [Small Animal Testing Center (SATC), Delivery Systems Initiative] - [In Vivo]
Matched on: category -->  Model System
mTmG is a double-fluorescent reporter transgenic mouse which expresses membrane-targeted tdTomato flanked by loxP sequences, followed by membrane-targeted GFP. After genomic cleavage by Cas9 at two sites, or Cre recombinase between loxP sites, tdTomato expression is lost and GFP is expressed.

24 results in Model Systems

Category Type Name Description View Associated..
Model System Animal Ai14 mouse Ai14 mouse has a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven red fluorescent protein variant (tdTomato) - all inserted into the Gt(ROSA)26Sor locus. The att site flanked neo selection cassette has been removed in this strain.
Model System Animal Ai14 mouse (congenic) Ai14 mouse has a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven red fluorescent protein variant (tdTomato) - all inserted into the Gt(ROSA)26Sor locus. The att site flanked neo selection cassette has been removed in this strain.
Model System Cell Ai14 mouse primary fibroblasts Primary fibroblasts from Ai14 mice
Model System Animal Ai9 mouse Ai9 mouse has a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven red fluorescent protein variant (tdTomato) - all inserted into the Gt(ROSA)26Sor locus.
Model System Animal Ai9 mouse (BCM) Ai9 mouse has a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven red fluorescent protein variant (tdTomato) - all inserted into the Gt(ROSA)26Sor locus.
Model System Cell Ai9 mouse immortalized fibroblasts Immortalized fibroblasts made from Ai9 (B6.Cg-Gt(ROSA)26Sor^tm9(CAG-tdTomato)Hze/J) mice
Model System Animal Ai9-SauSpyCas9 mouse Ai9-SauSpyCas9 is a version of Ai9 that has a single guide RNA sites on both sides of the STOP cassette. This is a Cre reporter allele that has a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven red fluorescent protein variant (tdTomato) - all inserted into the Gt(ROSA)26Sor locus. Ai9 mice express robust tdTomato fluorescence following Cre-mediated recombination.
Model System Animal BALB/c mouse BALB/cJ is a commonly used inbred. Key traits include a susceptibility to developing the demyelinating disease upon infection with Theiler's murine encephalomyelitis virus. The BALB/cJ substrain is susceptible to Listeria, all species of Leishmania, and several species of Trypanosoma, but is resistant to experimental allergic orchitis (EAO).
Model System Animal C57BL/6 mouse (Asokan study)
Model System Animal C57BL/6J mouse C57BL/6J WT mouse
Model System Cell CD4/CD8 Human Primary T cell CD4/CD8 Human Primary T cell
Model System Cell HEK-293-TgEF1a-eGFP-BSD HEK293 cells with lentiviral insertion of EF1a promoter driving expression of eGFP and SV40 promoter driving expression of BSD
Model System Cell HEK-293T with Ai9 transient reporter assay HEK-293T cells transfected with an Ai9 inducible transgene reporter plasmid used to test gene editing activity by fluorescence
Model System Cell HEK-293T-disrupted_GFP with MCV-mcherry-Puro HEK293T cells with an integrated reporter for TLR-MCV1 reporter editing
Model System Cell HEK-293T-disrupted_GFP-mcherry-Puro HEK293T cells with an integrated reporter for TLR1 reporter editing
Model System Cell Hepa1-6 Stable cell line
Model System K562
Model System Cell Mouse Embryonic Fibroblasts Primary cell line
Model System Cell NK
Model System Cell Neuro 2A Stable cell line
Model System Cell Primary Airway Epithelia Primary airway epithelia from non-CF donors
Model System Animal TLR-MCV1 TLR-MCV1 transgene knocked into Rosa26 locus
Model System Animal mTmG mouse ROSAmT/mG is a cell membrane-targeted, two-color fluorescent Cre-reporter allele. Prior to Cre recombination, cell membrane-localized tdTomato (mT) fluorescence expression is widespread in cells/tissues. Cre recombinase expressing cells (and future cell lineages derived from these cells) have cell membrane-localized EGFP (mG) fluorescence expression replacing the red fluorescence
Model System Animal mTmG mouse (congenic) mTmG is a double-fluorescent reporter transgenic mouse which expresses membrane-targeted tdTomato flanked by loxP sequences, followed by membrane-targeted GFP. After genomic cleavage by Cas9 at two sites, or Cre recombinase between loxP sites, tdTomato expression is lost and GFP is expressed.