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ExperimentBiomarker assays to evaluate toxicity induced by AAVs in iPS cell derived kidney organoids.
Experiment ConditionAAV2/2
Assay Description: KIM-1 levels were measured using the Meso Scale Discovery (MSD) platform
Tissue Measured:
Measurement Type:Biomarker Detection
Record ID15000003429

Editor
Delivery SystemAAV
Delivery System SubtypeViral vector
Guide
VectorAAV2/2CMVeGFP;

Model SpeciesHuman
Model NameHuman kidney organoid (iPSC-derived)

Application MethodVirus
Application Site
DosageMOI=10^5
Injection Frequency
Injection Rate
Injection Volume
Days post injection7 days
Editor FormatAAV encoded
Antidote Id
Antidote Description

Measured Values
Samples Size: 3
 
Replicate Result (Biomarker Detection)
Measurement Units: KIM-1 (pg/mL)
Mean 32.19 
1 26.32 
2 38.63 
3 31.62