Project: Human Microtissues for In Situ Detection and Functional Measurement of Adverse Consequences Caused by Genome Editing

PI:   Bruce Conklin, MD 

Genome editing technologies are poised to revolutionize the practice of modern medicine for the treatment of various types of genetic diseases. However, reliable testbed systems using human cells and tissues are needed to accurately predict both intended and unintended consequences of therapeutic interventions. The primary objective of this proposal is to develop and validate human tissue models capable of sensitively and accurately detecting adverse effects of genome editing on physiologic tissue function.