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Experiment Record Detail

ExperimentGene editing in vitro by various peptide variants delivering Cas12a in NK cells.
Experiment ConditionS10
Assay Description: Calculated editing efficiency by T7E1 digestion.
Tissue Measured:
Measurement Type:Editing Efficiency
Record ID15000000531
EditorAsCas12a (Feldan Therapeutics)
Delivery SystemS10
Delivery System SubtypeAmphiphilic peptide
GuideNKG2A
Vector
Model SpeciesHuman
Model NameNK
Application Method
Application Site
Dosage1.33uM Cas12a/2.0uM gRNA/7.5uM Shuttle Peptide
Injection Frequency
Injection Rate
Injection Volume
Days post injection48 hours
Editor Formatribonucleoprotein (RNP)
Antidote Id
Antidote Description
Measured Values
Samples Size: 3
 
Replicate Result (Editing Efficiency)
Measurement Units: % indel
Mean 24.99 
1 23.95680 
2 24.02615 
3 26.98109 
  

Associated Publications
Publication Title
Engineered amphiphilic peptides enable delivery of proteins and CRISPR-associated nucleases to airway epithelia. NCBI