Experiment Independent validation of Deverman delivery platform using engineered AAVs to deliver CRSIPR/Cas9 to mouse brain Experiment Condition Arm 3: Negative Control Saline, Males Assay Description: Qualitative assesment of tdTomato-negative cells throughout the entire brain Tissue Measured: brain Measurement Type: Editing Efficiency Record ID 15000001462 Editor Delivery System Delivery System Subtype Guide Vector Model Species Mouse Model Name B6.Cg-Gt(ROSA)26Sor ^ tm9(CAG-tdTomato)Hze/J Application Method Application Site brain Dosage Injection Frequency once Injection Rate Injection Volume 5 microliters/gram Days post injection 4 weeks Editor Format no editor Antidote Id Antidote Description Measured Values Samples Size: 3   Replicate Result (Editing Efficiency) Measurement Units: Signal Mean 3 of 3 absent  1 absent  2 absent  3 absent