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Project: Epigenome Editing Technologies for Treating Diverse Disease

PI:   Charles A Gersbach, PhD NIH Report

A recent revolution in DNA-targeting technologies has created new opportunities for treating human disease. While most effort has focused on using genome editing to alter DNA sequences to treat rare, inherited diseases, there is a tremendous opportunity to use these same tools to change the regulation of genes, rather than changing DNA sequence. This has the potential to extend the impact of these technologies to a greater diversity and number of diseases, and this proposal will address several key challenges to realizing this promise.
Summary of data submissions:
  • Data for 1  experiments were submitted on 2024-09-01 SCGE ID:1112

Submissions Details

SCGE ID:1112 - Submission Date: 2024-09-01 
Experiment Name Type Description
Genome editing activity of four Streptococcus Cas9s by gRNA targeting the HBE promoter in HEK293T cells.

In Vitro Genome editing activity of four Streptococcus Cas9s. Generation of insertions and deletions in the HBE promoter in HEK293T cells after co-transfection with plasmids encoding the respective Cas9 and corresponding sgRNA. Non-targeting values represent analysis of the region surrounding each targeting sgRNA in samples transfected with NT sgRNA.