Liver On Chip (LoC) | SCGE Toolkit

SCGE ID	13000000093
Name	Liver On Chip (LoC)
Species	human
Type	Organoid
Description	organoids derived from primary human hepatocytes
Parental Origin	Primary Human Hepatocytes (PHH)

This Model System: Liver On Chip (LoC) is being used ...

Project	Initiative	Contact PI
Comparing the efficiency and cellular impact of non-viral, hepatocyte-targeted delivery vehicles with viral-mediated gene delivery in a microphysiological liver on chip platform Experiments Testing different ratios of Lipofectamine-RNPs after 24 hours for determination of positive control Quantification of transfection efficiency by flow cytometry with varying dosages of nanoparticles encapsulated with Cas9/sgRNA RNP on liver-on-chip model system Imaging quantification of transfection efficiency with varying dosages of nanoparticles encapsulated with Cas9/sgRNA RNP on the liver-on-chip model system	Collaborative Opportunity Fund	Ross C. Wilson, PhD Samira Kiani, PhD Shaoqin (Sarah) Gong, PhD (University of Pittsburgh)

Model System: Liver On Chip (LoC)