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Experiment: Delivery of RNP containing chemically modified crRNA C20 with chemically modified tracrRNA T2-PS to determine the RNP distribution in TLR-MCV mouse brain

PI:   Erik J Sontheimer, PhD 

Chemically modified crRNA and tracrRNA were injected into the striatum of TLR-MCV mice and the distribution of RNP was imaged.
Delivery Assays: - Delivery and uptake testing of C20-Cy3/T2-PS (red fluorescence) and SpyCas9 by immunohistochemical staining (green fluorescecnce) after intrastriatal injections

Organ System Overview

Delivery Efficiency
Editing Efficiency
Target Tissue
Not Available

Analyze Data Sets Available for this Experiment
  Brain (unspecified)