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ExperimentCre Recombinase dose escalation study in Ai9 mice
Experiment ConditionAAVcc47-CMV-Cre, 1e12vg, Male
Assay Description: Delivery efficency in brain was calculated by counting the total number of TdTomato+ neurons and total number of NeuN+ cells
Tissue Measured:cerebral cortex
Cell Type :neuron
Measurement Type:Delivery Efficiency
Record ID15000000979

EditorCre recombinase
Delivery SystemAAV
Delivery System SubtypeViral vector
Guide
VectorAAVcc47-CMV-Cre;

Model SpeciesMouse
Model NameB6.Cg-Gt(ROSA)26Sor ^ tm9(CAG-tdTomato)Hze/J

Sample SexMale

Application Methodintravenous
Application Siteliver and heart
Dosage1e12vg
Injection Frequencyonce
Injection Rate
Injection Volume200 microliters
Days post injection4 weeks
Editor FormatAAV vector encoded
Antidote Id
Antidote Description

Measured Values
Samples Size: 1
 
Replicate Result (Delivery Efficiency)
Measurement Units: % of cells
Mean 2.78 
1 2.7767427360693304 
  

Publication Title
Cross-species evolution of a highly potent AAV variant for therapeutic gene transfer and genome editing. NCBI
Cross-species evolution of a highly potent AAV variant for therapeutic gene transfer and genome editing. NCBI