Experiment On-target editing compared to 14 circle-seq nominated off-target sites of adenine base editor delivered by BE-eVLP vs AAV in the C57BL/6 liver Experiment Condition OT8 (A4)-Untreated Assay Description: adenine base editing at target Pcsk9 site in liver vs. other mouse organs (heart, kidney, lung, muscle, spleen) Tissue Measured: liver Measurement Type: Editing Efficiency Record ID 15000001569 Editor Delivery System Delivery System Subtype Guide Vector Model Species Mouse Model Name C57BL/6J Application Method Application Site liver Dosage Injection Frequency Injection Rate Injection Volume Days post injection 9 week Editor Format Antidote Id Antidote Description Measured Values Samples Size: 3   Replicate Result (Editing Efficiency) Measurement Units: % of total sequencing reads with AT converted to GC Mean 0.01  1 0.018225  2 0.010818  3 0.013913