TadA-8e V106W | SCGE Toolkit

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SCGE ID	11000000151
Symbol	TadA-8e V106W
Description	Catalytically impaired Cas fused to evolved TadA deaminase (TadA-8e V106W)
Species	(Cas) S. pyogenes TadA (E. coli)
Type	Base Editor (SpCas9)
Subtype	Adenine base editor

Activity	Deaminase
Substrate	double stranded DNA
PAM	NGG
Variant	TadA-8e V106W

Source	Chaikof Lab

CCCATACCTTGGAGCAACGG

Publication Title
Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins. NCBI

This Genome Editor: TadA-8e V106W is being used

Project	Initiative	Contact PI
Delivery Technologies for In Vivo Genome Editing Experiments Pcsk9 adenine base editor efficiency in liver and nonliver tissue On-target editing compared to 14 circle-seq nominated off-target sites of adenine base editor delivered by BE-eVLP vs AAV in the C57BL/6 liver	Delivery Systems Initiative	Elliot L. Chaikof, MD, PhD (Beth Israel Deaconess Medical Center)