SCGE ID10000000291
Lab IDPcsk9 Exon 1 splice domain
SourceSynthego
Target LocusPcsk9 Exon 1 splice domain
Speciesmouse
DescriptionPcsk9 Exon 1 splice domain
Guide CompatibilitySpyCas9

Target SequenceCCCATACCTTGGAGCAACGG
Target Sequence + PAMCCCATACCTTGGAGCAACGGCGG
PositionGRCm38/mm10/4.0:106463688-106463707

Spacer SequenceCCCAUACCUUGGAGCAACGG
Spacer Length20
Modifications2' O-METHYL FOR FIRST 3 AND LAST 3 BASES, PHOSPHOROTHIOATE BONDS BETWEEN THE FIRST 3 AND LAST 2 BASES

  • STS134 (PCSK9b; Sp_t2:Sp_c20_PCSK9b)

  • TadA-8e V106W

  • ABE8e



  • Publication Title
    Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins. NCBI

    This Guide: Pcsk9 Exon 1 splice domain is being used ...
    Project Initiative Contact PI
    Delivery Systems Elliot L. Chaikof, MD, PhD
    (Beth Israel Deaconess Medical Center)
    NIH Report
    Animal Reporter and Testing Center Jason D Heaney, PhD
    (Baylor College of Medicine)
    NIH Report