SCGE ID10000000291
Lab IDPcsk9 Exon 1 splice domain
SourceSynthego
Target LocusPcsk9 Exon 1 splice domain
Speciesmouse
DescriptionPcsk9 Exon 1 splice domain
Guide CompatibilitySpyCas9

Target SequenceCCCATACCTTGGAGCAACGG
Target Sequence + PAMCCCATACCTTGGAGCAACGGCGG
PositionGRCm38/mm10/4.0:106463688-106463707

Spacer SequenceCCCAUACCUUGGAGCAACGG
Spacer Length20
Modifications2' O-METHYL FOR FIRST 3 AND LAST 3 BASES, PHOSPHOROTHIOATE BONDS BETWEEN THE FIRST 3 AND LAST 2 BASES

  • STS134 (PCSK9b; Sp_t2:Sp_c20_PCSK9b)

  • TadA-8e V106W

  • ABE8e



  • Publication Title
    Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins. NCBI

    This Guide: Pcsk9 Exon 1 splice domain is being used ...
    Project Initiative Contact PI
    Delivery Systems Initiative Elliot L. Chaikof, MD, PhD
    (Beth Israel Deaconess Medical Center)
    NIH Report
    Animal Reporter and Testing Center Initiative Jason D Heaney, PhD
    (Baylor College of Medicine)
    NIH Report