On-target editing compared to 14 circle-seq nominated off-target sites of adenine base editor delivered by BE-eVLP vs AAV in the C57BL/6 liver |
OT8 (A4)-AAV |
adenine base editing at target Pcsk9 site in liver vs. other mouse organs (heart, kidney, lung, muscle, spleen) |
liver |
Editing Efficiency |
15000001555 |
|
TadA-8e V106W |
|
|
|
AAV-Pcsk9; |
|
Mouse |
C57BL/6J |
|
retro-orbital (intravenous) |
liver |
1E11 vg |
1x |
|
120 ul |
1 week |
AAV |
|
|
|
Measured Values |
Samples Size: | 5 |
|
Mean |
0.01  |
1 |
0.011838  |
2 |
0.016724  |
3 |
0  |
4 |
0.024128  |
5 |
0.016258  |
| |
|