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 SaCas9 (AAV-SaCas9)
Guide Target Locus
 DMD
  Guides
 DMD low gRNA-1
 DMD low gRNA-2
Delivery Systems
 AAV
Models
 Human kidney organoid (stem cell-derived)
  Vectors
 AAV2-SaCas9
 AAV2-gRNA
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Results

Delivery_of_saCas9_and_gRNAs_to_nephron_epithelia_by_AAV2_in_kidney_organoids.
Delivery Efficiency
Record Id Condition Editor Model Delivery Target Locus Guide Vector Dosage Delivery Efficiency % of LTL+ cells Delivery Efficiency % of CDH+ cells Delivery Efficiency % of PODXL+ cells Image
15000003432 Cas9+, mCherry+ in LTL Stained Cells SaCas9 (AAV-SaCas9) Human kidney organoid (stem cell-derived) AAV DMD DMD low gRNA-1DMD low gRNA-2 AAV2-gRNA; AAV2-SaCas9 MOI=10^5
15000003433 Cas9+, mCherry+ in CDH1 Stained Cells SaCas9 (AAV-SaCas9) Human kidney organoid (stem cell-derived) AAV DMD DMD low gRNA-1DMD low gRNA-2 AAV2-gRNA; AAV2-SaCas9 MOI=10^5
15000003434 Cas9+, mCherry+ in PODXL Stained Cells SaCas9 (AAV-SaCas9) Human kidney organoid (stem cell-derived) AAV DMD DMD low gRNA-1DMD low gRNA-2 AAV2-gRNA; AAV2-SaCas9 MOI=10^5
15000003435 Cas9+ mCherry- in LTL Stained Cells SaCas9 (AAV-SaCas9) Human kidney organoid (stem cell-derived) AAV DMD DMD low gRNA-1DMD low gRNA-2 AAV2-gRNA; AAV2-SaCas9 MOI=10^5
15000003436 Cas9+ mCherry- in CDH1 Stained Cells SaCas9 (AAV-SaCas9) Human kidney organoid (stem cell-derived) AAV DMD DMD low gRNA-1DMD low gRNA-2 AAV2-gRNA; AAV2-SaCas9 MOI=10^5
15000003437 Cas9+ mCherry- in PODXL Stained Cells SaCas9 (AAV-SaCas9) Human kidney organoid (stem cell-derived) AAV DMD DMD low gRNA-1DMD low gRNA-2 AAV2-gRNA; AAV2-SaCas9 MOI=10^5
15000003438 Cas9- mCherry+ in LTL Stained Cells SaCas9 (AAV-SaCas9) Human kidney organoid (stem cell-derived) AAV DMD DMD low gRNA-1DMD low gRNA-2 AAV2-gRNA; AAV2-SaCas9 MOI=10^5
15000003439 Cas9- mCherry+ in CDH1 Stained Cells SaCas9 (AAV-SaCas9) Human kidney organoid (stem cell-derived) AAV DMD DMD low gRNA-1DMD low gRNA-2 AAV2-gRNA; AAV2-SaCas9 MOI=10^5
15000003440 Cas9- mCherry+ in PODXL Stained Cells SaCas9 (AAV-SaCas9) Human kidney organoid (stem cell-derived) AAV DMD DMD low gRNA-1DMD low gRNA-2 AAV2-gRNA; AAV2-SaCas9 MOI=10^5

Evaluation on delivery of saCas9 and gRNAs by AAV2 in kidney organoids.