Experiment Independent validation of Chaikof delivery platform using virus-like particle (VLP) delivery to the mouse liver Experiment Condition Female (Experimental) Assay Description: Targeted next generation sequencing (NGS) Tissue Measured: kidney Measurement Type: Editing Efficiency Record ID 15000003573 Editor ABE8e Delivery System eVLP Delivery System Subtype Virus Like Particle Guide Pcsk9 Exon 1 splice domain Vector Model Species Mouse Model Name B6 Sample Age 6 weeks Sample Sex Female Application Method intravenous, tail vein Application Site liver Dosage 5E11 particles Injection Frequency once Injection Rate Injection Volume 100 microliters Days post injection Editor Format ribonucleoprotein (RNP) Antidote Id Antidote Description Measured Values Samples Size: 3   Replicate Result (Editing Efficiency) Measurement Units: % of reads Mean 0.23  1 0.1  2 0.3  3 0.3