| 
        
            
            | Pcsk9 adenine base editor efficiency in liver and nonliver tissue |  | BE-eVLP-Pcsk9 |  
                | adenine base editing at target Pcsk9 site in liver vs. other mouse organs (heart, kidney, lung, muscle, spleen) |  
                | heart |  
                | Editing Efficiency |  | 15000001520 |  | 
 |  | TadA-8e V106W |  | eVLP |  | Virus Like Particle |  | Pcsk9 Exon 1 splice domain |  |  |  | 
 |  | Mouse |  | C57BL/6J |  | 
 |  | Male |  | 
 |  | intravenous, retro-orbital |  | liver |  |  |  | once |  |  |  | 120 microliters |  | 1 week |  | ribonucleoprotein (RNP) |  |  |  |  |  | 
 |  
                | Measured Values |  
                | Samples Size: | 4 |  |  |  
                
                
             
                 
                     
                     
                      
                
                | Mean | 0.39  |  
                
                | 1 | 0.07728  |  
                
                | 2 | 0.526614  |  
                
                | 3 | 0.233053  |  
                
                | 4 | 0.735908  |  |  |  |