Pcsk9 adenine base editor efficiency in liver and nonliver tissue |
BE-eVLP-Pcsk9 |
adenine base editing at target Pcsk9 site in liver vs. other mouse organs (heart, kidney, lung, muscle, spleen) |
liver |
Editing Efficiency |
15000001522 |
|
TadA-8e V106W |
eVLP |
Virus Like Particle |
Pcsk9 Exon 1 splice domain |
|
|
Mouse |
C57BL/6J |
|
intravenous, retro-orbital |
liver |
|
once |
|
120 microliters |
1 week |
ribonucleoprotein (RNP) |
|
|
|
Measured Values |
Samples Size: | 4 |
|
Mean |
62.7  |
1 |
66.86291  |
2 |
63.96256  |
3 |
63.03747  |
4 |
56.94344  |
| |
|