| Pcsk9 adenine base editor efficiency in liver and nonliver tissue |
| BE-eVLP-Pcsk9 |
| adenine base editing at target Pcsk9 site in liver vs. other mouse organs (heart, kidney, lung, muscle, spleen) |
| spleen |
| Editing Efficiency |
| 15000001525 |
|
| TadA-8e V106W |
| eVLP |
| Virus Like Particle |
| Pcsk9 Exon 1 splice domain |
|
|
| Mouse |
| C57BL/6J |
|
| 6-8 weeks |
| Male |
|
| intravenous, retro-orbital |
| liver |
|
| once |
|
| 120 microliters |
| 1 week |
| ribonucleoprotein (RNP) |
|
|
|
| Measured Values |
| Samples Size: | 4 |
| |
| Mean |
4.28  |
| 1 |
4.463924  |
| 2 |
4.762608  |
| 3 |
5.058986  |
| 4 |
2.83907  |
| |
|