Summary

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Projects & Experiments

This Delivery System: FSD315 is being used ...

Project	Initiative	Contact PI
Delivery of CRISPR Ribonucleoproteins to Airway Epithelia Using Novel Amphiphilic Peptides Experiments Peptide Shuttle optimization to deliver Cas12a RNP to human airway epithelia cells Peptide Shuttle optimization to deliver Cas9 RNP to human airway epithelia cells	Delivery Systems	Paul B McCray, Jr, MD (University of Iowa)
Base Editing in Rhesus Airway Epithelial Experiments Delivery of Cas9 RNP using Shuttle peptide candidates to human airway epithelial cells cultured at the air liquid interface targeting CFTR locus Amphiphilic Peptides Deliver Base Editor RNPs to Rhesus Monkey Airway Delivery of ABE8e-Cas9 RNP using Shuttle peptide candidates to rhesus monkey airway epithelial cells cultured at the air liquid interface targeting CCR5 locus. Delivery of ABE8e-Cas9 RNP using Shuttle peptide candidates to human airway epithelial cells cultured at the air liquid interface targeting B2M locus Inhibitory effect of Cas9 RNP alone on S10- or FSDS315-mediated GFP protein delivery to HeLa cells	Collaborative Opportunity Fund	Paul B McCray, Jr, MD Alice F Tarantal, PhD David Guay, PhD David R Liu, PhD (University of Iowa)