Contact SCGE




SCGE Consortium Home   |  About SCGE Toolkit   |  Contact Us   |  Citing the Toolkit   |  License  
 
Filters ..
  Tissues
Respiratory
  • Trachea (tracheal epithelial cell)
  • Left main bronchus (bronchial epithelial cell)
  • Lobar bronchus of left lung upper lobe (bronchial epithelial cell)
  • Lingula of left lung (bronchial epithelial cell)
  • Lobar bronchus of left lung lower lobe (bronchial epithelial cell)
  • Left lung lower lobe bronchiole (bronchial epithelial cell)
  • Right main bronchus (bronchial epithelial cell)
  • Lobar bronchus of right lung cranial lobe (bronchial epithelial cell)
  • Lobar bronchus of right lung middle lobe (bronchial epithelial cell)
  • Lobar bronchus of right lung caudal lobe (bronchial epithelial cell)
  • Lower respiratory tract epithelium (ciliated epithelial cell)
  • Lower respiratory tract epithelium (lung secretory cell)
  • Lower respiratory tract epithelium (type II pneumocyte)
  • Lower respiratory tract epithelium (basal epithelial cell of tracheobronchial tree)
  Cell Types
 basal epithelial cell of tracheobronchial tree
 bronchial epithelial cell
 ciliated epithelial cell
 lung secretory cell
 tracheal epithelial cell
 type II pneumocyte
Editors
 ABE8e-Cas9
Guide Target Locus
 CCR5
Guides
 gRNA #8
  Delivery Systems
 FSD315
 S10
Models
 Macaca mulatta (Rhesus Macaque)
  Sex
 Female
 Male
Select experimental variable to highlight records on the chart: 
 

Note: Hover over the bars to view additional information

Loading...

Results

Amphiphilic_Peptides_Deliver_Base_Editor_RNPs_to__Rhesus_Monkey_Airway
Editing Efficiency Delivery Efficiency
Record Id Condition Tissue Cell Type Sex Editor Model Delivery Target Locus Guide Dosage Injection Frequency Editing Efficiency % of A•T basepairs converted to G•C Delivery Efficiency Signal Image
15000002990 S10 and ABE8e-Cas9 RNP trachea tracheal epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) S10 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM S10 amphiphilic peptide once
15000002991 S10 and ABE8e-Cas9 RNP left main bronchus bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) S10 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM S10 amphiphilic peptide once
15000002992 S10 and ABE8e-Cas9 RNP lobar bronchus of left lung upper lobe bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) S10 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM S10 amphiphilic peptide once
15000002993 S10 and ABE8e-Cas9 RNP lingula of left lung bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) S10 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM S10 amphiphilic peptide once
15000002994 S10 and ABE8e-Cas9 RNP lobar bronchus of left lung lower lobe bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) S10 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM S10 amphiphilic peptide once
15000002995 S10 and ABE8e-Cas9 RNP left lung lower lobe bronchiole bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) S10 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM S10 amphiphilic peptide once
15000002996 S10 and ABE8e-Cas9 RNP right main bronchus bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) S10 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM S10 amphiphilic peptide once
15000002997 S10 and ABE8e-Cas9 RNP lobar bronchus of right lung cranial lobe bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) S10 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM S10 amphiphilic peptide once
15000002998 S10 and ABE8e-Cas9 RNP lobar bronchus of right lung middle lobe bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) S10 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM S10 amphiphilic peptide once
15000002999 S10 and ABE8e-Cas9 RNP lobar bronchus of right lung caudal lobe bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) S10 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM S10 amphiphilic peptide once
15000003000 ABE8e-Cas9 RNP trachea tracheal epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9 once
15000003001 ABE8e-Cas9 RNP left main bronchus bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9 once
15000003002 ABE8e-Cas9 RNP lobar bronchus of left lung upper lobe bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9 once
15000003003 ABE8e-Cas9 RNP lingula of left lung bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9 once
15000003004 ABE8e-Cas9 RNP lobar bronchus of left lung lower lobe bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9 once
15000003005 ABE8e-Cas9 RNP left lung lower lobe bronchiole bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9 once
15000003006 ABE8e-Cas9 RNP right main bronchus bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9 once
15000003007 ABE8e-Cas9 RNP lobar bronchus of right lung cranial lobe bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9 once
15000003008 ABE8e-Cas9 RNP lobar bronchus of right lung middle lobe bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9 once
15000003009 ABE8e-Cas9 RNP lobar bronchus of right lung caudal lobe bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9 once
15000003010 FSD315 and ABE8e-Cas9 RNP (animal 1) trachea tracheal epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) FSD315 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM FSD315 amphiphilic peptide once
15000003011 FSD315 and ABE8e-Cas9 RNP (animal 1) left main bronchus bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) FSD315 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM FSD315 amphiphilic peptide once
15000003012 FSD315 and ABE8e-Cas9 RNP (animal 1) lobar bronchus of left lung upper lobe bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) FSD315 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM FSD315 amphiphilic peptide once
15000003013 FSD315 and ABE8e-Cas9 RNP (animal 1) lingula of left lung bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) FSD315 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM FSD315 amphiphilic peptide once
15000003014 FSD315 and ABE8e-Cas9 RNP (animal 1) lobar bronchus of left lung lower lobe bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) FSD315 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM FSD315 amphiphilic peptide once
15000003015 FSD315 and ABE8e-Cas9 RNP (animal 1) left lung lower lobe bronchiole bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) FSD315 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM FSD315 amphiphilic peptide once
15000003016 FSD315 and ABE8e-Cas9 RNP (animal 1) right main bronchus bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) FSD315 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM FSD315 amphiphilic peptide once
15000003017 FSD315 and ABE8e-Cas9 RNP (animal 1) lobar bronchus of right lung cranial lobe bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) FSD315 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM FSD315 amphiphilic peptide once
15000003018 FSD315 and ABE8e-Cas9 RNP (animal 1) lobar bronchus of right lung middle lobe bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) FSD315 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM FSD315 amphiphilic peptide once
15000003019 FSD315 and ABE8e-Cas9 RNP (animal 1) lobar bronchus of right lung caudal lobe bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) FSD315 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM FSD315 amphiphilic peptide once
15000003020 FSD315 and ABE8e-Cas9 RNP (animal 2) trachea tracheal epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) FSD315 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM FSD315 amphiphilic peptide once
15000003021 FSD315 and ABE8e-Cas9 RNP (animal 2) left main bronchus bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) FSD315 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM FSD315 amphiphilic peptide once
15000003022 FSD315 and ABE8e-Cas9 RNP (animal 2) lobar bronchus of left lung upper lobe bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) FSD315 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM FSD315 amphiphilic peptide once
15000003023 FSD315 and ABE8e-Cas9 RNP (animal 2) lingula of left lung bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) FSD315 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM FSD315 amphiphilic peptide once
15000003024 FSD315 and ABE8e-Cas9 RNP (animal 2) lobar bronchus of left lung lower lobe bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) FSD315 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM FSD315 amphiphilic peptide once
15000003025 FSD315 and ABE8e-Cas9 RNP (animal 2) left lung lower lobe bronchiole bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) FSD315 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM FSD315 amphiphilic peptide once
15000003026 FSD315 and ABE8e-Cas9 RNP (animal 2) right main bronchus bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) FSD315 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM FSD315 amphiphilic peptide once
15000003027 FSD315 and ABE8e-Cas9 RNP (animal 2) lobar bronchus of right lung cranial lobe bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) FSD315 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM FSD315 amphiphilic peptide once
15000003028 FSD315 and ABE8e-Cas9 RNP (animal 2) lobar bronchus of right lung middle lobe bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) FSD315 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM FSD315 amphiphilic peptide once
15000003029 FSD315 and ABE8e-Cas9 RNP (animal 2) lobar bronchus of right lung caudal lobe bronchial epithelial cell Female ABE8e-Cas9 Macaca mulatta (Rhesus Macaque) FSD315 CCR5 gRNA #8 2 uM gRNA, 2.5 uM Cas9, 40 uM FSD315 amphiphilic peptide once
15000003030 S10 and DRI-NLS-Cy5 (10 uM) trachea tracheal epithelial cell Male Macaca mulatta (Rhesus Macaque) S10 10 uM DRI-NLS-Cy5, 40 uM S10 amphiphilic peptide once
15000003031 S10 and DRI-NLS-Cy5 (10 uM) lobar bronchus of left lung lower lobe bronchial epithelial cell Male Macaca mulatta (Rhesus Macaque) S10 10 uM DRI-NLS-Cy5, 40 uM S10 amphiphilic peptide once
15000003032 S10 and DRI-NLS-Cy5 (10 uM) lower respiratory tract epithelium ciliated epithelial cell Male Macaca mulatta (Rhesus Macaque) S10 10 uM DRI-NLS-Cy5, 40 uM S10 amphiphilic peptide once
15000003033 S10 and DRI-NLS-Cy5 (10 uM) lower respiratory tract epithelium lung secretory cell Male Macaca mulatta (Rhesus Macaque) S10 10 uM DRI-NLS-Cy5, 40 uM S10 amphiphilic peptide once
15000003034 S10 and DRI-NLS-Cy5 (10 uM) lower respiratory tract epithelium type II pneumocyte Male Macaca mulatta (Rhesus Macaque) S10 10 uM DRI-NLS-Cy5, 40 uM S10 amphiphilic peptide once
15000003035 S10 and DRI-NLS-Cy5 (10 uM) lower respiratory tract epithelium basal epithelial cell of tracheobronchial tree Male Macaca mulatta (Rhesus Macaque) S10 10 uM DRI-NLS-Cy5, 40 uM S10 amphiphilic peptide once
15000003036 DRI-NLS-Cy5 (10 uM) trachea tracheal epithelial cell Male Macaca mulatta (Rhesus Macaque) 10 uM DRI-NLS-Cy5 once
15000003037 DRI-NLS-Cy5 (10 uM) lobar bronchus of left lung lower lobe bronchial epithelial cell Male Macaca mulatta (Rhesus Macaque) 10 uM DRI-NLS-Cy5 once
15000003038 DRI-NLS-Cy5 (10 uM) lower respiratory tract epithelium ciliated epithelial cell Male Macaca mulatta (Rhesus Macaque) 10 uM DRI-NLS-Cy5 once
15000003039 DRI-NLS-Cy5 (10 uM) lower respiratory tract epithelium lung secretory cell Male Macaca mulatta (Rhesus Macaque) 10 uM DRI-NLS-Cy5 once
15000003040 DRI-NLS-Cy5 (10 uM) lower respiratory tract epithelium type II pneumocyte Male Macaca mulatta (Rhesus Macaque) 10 uM DRI-NLS-Cy5 once
15000003041 DRI-NLS-Cy5 (10 uM) lower respiratory tract epithelium basal epithelial cell of tracheobronchial tree Male Macaca mulatta (Rhesus Macaque) 10 uM DRI-NLS-Cy5 once