306-S10 | SCGE Toolkit

SCGE ID	12000000164
Name	306-S10
Description	combinatorial library cationic lipid nanoparticles
Type	Nanoparticle
Subtype	cationic lipid

Source	Xu lab

Nanoparticle Size	100-300 nm

This Delivery System: 306-S10 is being used ...

Project	Initiative	Contact PI
Efficient In Vivo RNP-Based Gene Editing in the Sensory Organ Inner Ear Using Bioreducible Lipid Nanoparticles Experiments Testing new LNPs (lipid nanoparticles) for delivery of Cas9 mRNA/sgRNA in primary fibroblast cells from adult Ai14 mouse cochlea Testing new LNPs (lipid nanoparticles) for delivery of Cas9 mRNA/sgRNA in adult mouse cochlea Testing new LNPs (lipid nanoparticles) for delivery of Fluc mRNA in adult mice	Delivery Systems	Zheng-Yi Chen, PhD (Massachusetts Eye & Ear Infirmary)
The Jackson Laboratory Gene Editing Testing Center (JAX-GETC) Experiments Independent validation of Chen delivery platform using LNPs to deliver CRISPR/Cas9 to mouse inner ear Independent validation of Chen delivery platform using LNPs to deliver CRISPR/Cas9 to mouse inner ear	Animal Reporter and Testing Center	Stephen A Murray, PhD (Jackson Laboratory)

Delivery System: 306-S10