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Project: The Jackson Laboratory Gene Editing Testing Center (JAX-GETC)

PI:   Stephen A Murray, PhD 
Description: The revolution in gene editing technology promises to transform the development of therapeutics to treat human disease. As part of the Somatic Cell Genome Editing consortium, the goal of this project is to build mouse resources and provide an animal model testing platform to support the optimization of novel genome editing technologies for future translational applications.

VALIDATION - The Jackson Laboratory Gene Editing Testing Center - Chen Validation (Chen, Zheng-Yi)
SCGE ID:1044 - Submission Date: 2021-04-01 
Experiment Name Type Description
Second site validation of Chen delivery platform using LNPs to deliver CRISPR/Cas9 to mouse inner ear
In Vivo Delivery of CRISPR/Cas9 via bioreducible lipid nanoparticles (LNPs) to the inner ear in Ai14 mice
Repeat experiment of second site validation of Chen delivery platform using LNPs to deliver CRISPR/Cas9 to mouse inner ear
In Vivo Delivery of CRISPR/Cas9 editor via bioreducible lipid nanoparticle to the inner ear in Ai14 mice
VALIDATION - The Jackson Laboratory Gene Editing Testing Center - Gong Validation (Gong, Shaoqin)
SCGE ID:1046 - Submission Date: 2021-04-01 
Experiment Name Type Description
Second site validation of Gong delivery platform using RNP-loaded nanocages to deliver CRISPR/Cas9 to mouse brain
In Vivo Delivery of CRISPR/Cas9 via RNP-loaded nanocages to the brain in Ai14 mice