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Experiment: Testing new LNPs (lipid nanoparticles) for delivery of Cas9 mRNA/sgRNA in adult mouse cochlea

PI:   Zheng-Yi Chen, PhD 
 

Delivery of Cas9/sgRNA mRNA via new LNPs to the cochlea by cochleostomy and gene editing is measured by percentage of tdTomato positive cells.
Editing Assay: - Editing efficiency is calculated by percentage of tdTomato positive cells

Organ System Overview


 
306-O12B
113-O12B
306-S10
Legend:  
Delivery Efficiency
Editing Efficiency
Target Tissue
Not Available
 

 
Analyze Data Sets Available for this Experiment
Sensory
  Base of cochlear canal (Deiter's cell)
  Scala tympani (Deiter's cell)
  Base of cochlear canal (cochlear inner hair cell)
  Base of cochlear canal (external pillar cell of cochlea)
  Scala tympani (cochlear inner hair cell)
  Stria vascularis of cochlear duct (unspecified)