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  Tissues
Sensory
  • Base of cochlear canal (Deiter's cell)
  • Scala tympani (Deiter's cell)
  • Base of cochlear canal (cochlear inner hair cell)
  • Base of cochlear canal (external pillar cell of cochlea)
  • Scala tympani (cochlear inner hair cell)
  • Stria vascularis of cochlear duct
  Cell Types
 Deiter's cell
 cochlear inner hair cell
 external pillar cell of cochlea
Editors
 CleanCap┬« Cas9
Guide Target Locus
 Ai9/Ai14 reporter transgene
Guides
 sg298
  Delivery Systems
 113-O12B
 306-O12B
 306-S10
Models
 Ai14 mouse (congenic)
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Results

Testing_new_LNPs_(lipid_nanoparticles)_for_delivery_of_Cas9_mRNA/sgRNA_in_adult_mouse_cochlea
Editing Efficiency
Record Id Condition Tissue Cell Type Editor Model Delivery Target Locus Guide Dosage Injection Frequency Editing Efficiency % of cells Image
15000000594 306-O12B base of cochlear canal Deiter's cell CleanCap® Cas9 Ai14 mouse (congenic) 306-O12B Ai9/Ai14 reporter transgene sg298 LNP/Cas9/sgRNA=0.15/0.01/0.01ug once
15000000595 306-O12B scala tympani Deiter's cell CleanCap® Cas9 Ai14 mouse (congenic) 306-O12B Ai9/Ai14 reporter transgene sg298 LNP/Cas9/sgRNA=0.15/0.01/0.01ug once
15000000596 113-O12B base of cochlear canal Deiter's cell CleanCap® Cas9 Ai14 mouse (congenic) 113-O12B Ai9/Ai14 reporter transgene sg298 LNP/Cas9/sgRNA=0.15/0.01/0.01ug once
15000000597 113-O12B base of cochlear canal cochlear inner hair cell CleanCap® Cas9 Ai14 mouse (congenic) 113-O12B Ai9/Ai14 reporter transgene sg298 LNP/Cas9/sgRNA=0.15/0.01/0.01ug once
15000000598 306-S10 base of cochlear canal Deiter's cell CleanCap® Cas9 Ai14 mouse (congenic) 306-S10 Ai9/Ai14 reporter transgene sg298 LNP/Cas9/sgRNA=0.15/0.01/0.01ug once
15000000599 306-S10 scala tympani Deiter's cell CleanCap® Cas9 Ai14 mouse (congenic) 306-S10 Ai9/Ai14 reporter transgene sg298 LNP/Cas9/sgRNA=0.15/0.01/0.01ug once
15000000600 306-S10 base of cochlear canal external pillar cell of cochlea CleanCap® Cas9 Ai14 mouse (congenic) 306-S10 Ai9/Ai14 reporter transgene sg298 LNP/Cas9/sgRNA=0.15/0.01/0.01ug once
15000000601 306-S10 scala tympani cochlear inner hair cell CleanCap® Cas9 Ai14 mouse (congenic) 306-S10 Ai9/Ai14 reporter transgene sg298 LNP/Cas9/sgRNA=0.15/0.01/0.01ug once
15000000602 306-S10 stria vascularis of cochlear duct CleanCap® Cas9 Ai14 mouse (congenic) 306-S10 Ai9/Ai14 reporter transgene sg298 LNP/Cas9/sgRNA=0.15/0.01/0.01ug once