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Experiment: Testing new LNPs (lipid nanoparticles) for delivery of Cas9 mRNA/sgRNA in adult mouse cochlea

PI:   Zheng-Yi Chen, PhD 
 

Delivery of Cas9/sgRNA mRNA via new LNPs to the cochlea by cochleostomy and gene editing is measured by percentage of tdTomato positive cells.
Editing Assay: - Editing efficiency is calculated by percentage of tdTomato positive cells

Organ System Overview
Legend:  
Delivery Efficiency
Editing Efficiency
Target Tissue
Not Studied


 
306-O12B
113-O12B
306-S10
 

 
Analyze Data Sets Available for this ExperimentDeliveryEditing
Sensory
  Base of cochlear canal (Deiter's cell) n/a
  Scala tympani (Deiter's cell) n/a
  Base of cochlear canal (cochlear inner hair cell) n/a
  Base of cochlear canal (external pillar cell of cochlea) n/a
  Scala tympani (cochlear inner hair cell) n/a
  Stria vascularis of cochlear duct n/a