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Experiment: Testing gRNA sequence and gRNA scaffold modified in Ai9 mice.

PI:   Benjamin E Deverman, PhD 
 

3e11 vg/mouse of AAV-BI28:GFAP-SaCas9-WPRE-pA and 3e11 vg/mouse of AAV-BI28:GFAP-NLS-GFP-U6-L1-U6-R2 were codelivered intravenously to adult male and female Ai9 mice. Editing was assessed in brain sections 4 weeks later.
Editing Assay: - Editing efficiency assessed by quantifying tdTomato positive area above threshold

Organ System Overview


 
Male
Female
Legend:  
Delivery Efficiency
Editing Efficiency
Target Tissue
Not Available
 

 
Analyze Data Sets Available for this Experiment
Nervous
  Cerebral cortex (astrocyte)  (TARGET)
  Dorsal plus ventral thalamus (astrocyte)  (TARGET)
  Striatum (astrocyte)  (TARGET)