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Experiment: Repeat experiment of second site validation of Chen delivery platform using LNPs to deliver CRISPR/Cas9 to mouse inner ear

PI:   Stephen A Murray, PhD 
 

Delivery of CRISPR/Cas9 editor via bioreducible lipid nanoparticle to the inner ear in Ai14 mice
Editing Assay: - Confocal Imaging of mouse cochlea, direct fluorescence RFP (tdTomato) compared to Hoechst stained nuclei.

Organ System Overview


 
Arm 1 (Repeat 4/20/21): 306-O12B LNP containing Cas9 mRNA and sgRNA
Control (Repeat 4/20/21): 306-O12B LNP without Cas9 mRNA and sgRNA
Legend:  
Delivery Efficiency
Editing Efficiency
Target Tissue
Not Available
 

 
Analyze Data Sets Available for this Experiment
Sensory
  Base of cochlear canal (unspecified)
  Scala tympani (unspecified)