306-O12B | SCGE Toolkit

SCGE ID	12000000163
Name	306-O12B
Description	Combinatorial library cationic lipid nanoparticles
Type	Nanoparticle
Subtype	cationic lipid

Source	Xu lab

Nanoparticle Size	100-300 nm
Zeta Potential	25 mV
Poly Dispersity Index	0.3

This Delivery System: 306-O12B is being used ...

Project	Initiative	Contact PI
Efficient In Vivo RNP-Based Gene Editing in the Sensory Organ Inner Ear Using Bioreducible Lipid Nanoparticles Experiments Testing new LNPs (lipid nanoparticles) for delivery of Cas9 mRNA/sgRNA in primary fibroblast cells from adult Ai14 mouse cochlea Testing new LNPs (lipid nanoparticles) for delivery of Fluc mRNA in adult mice Testing new LNPs (lipid nanoparticles) for delivery of Cas9 mRNA/sgRNA in adult mouse cochlea	Delivery Systems	Zheng-Yi Chen, PhD (Massachusetts Eye & Ear Infirmary)
The Jackson Laboratory Gene Editing Testing Center (JAX-GETC) Experiments Repeat experiment of independent validation of Chen delivery platform using LNPs to deliver CRISPR/Cas9 to mouse inner ear Repeat experiment of independent validation of Chen delivery platform using LNPs to deliver CRISPR/Cas9 to mouse inner ear Independent validation of Chen delivery platform using LNPs to deliver CRISPR/Cas9 to mouse inner ear Independent validation of Chen delivery platform using LNPs to deliver CRISPR/Cas9 to mouse inner ear	Animal Reporter and Testing Center	Stephen A Murray, PhD (Jackson Laboratory)

Delivery System: 306-O12B