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Experiment: Second site validation of Gong delivery platform using RNP-loaded nanocages to deliver CRISPR/Cas9 to mouse brain

PI:   Stephen A Murray, PhD 
 

Delivery of CRISPR/Cas9 via RNP-loaded nanocages to the brain in Ai14 mice
Editing Assay: - Editing efficiency calculated by counting the number of Edited Neurons (NeuN+/GFP+ and TdTomato+/RFP+) out of the total number of neurons (NeuN+/GFP+) in a defined region of interest in the brain, expressed as a percentage of neurons in the ROI.

Organ System Overview
Legend:  
Delivery Efficiency
Editing Efficiency
Target Tissue
Not Studied


 
NC-RVG Females
NC No Ligand Male
NC-CPP Males
NC-CPP Females
NC-RVG Males
NC No Ligand Female
 

 
Analyze Data Sets Available for this ExperimentDeliveryEditing
Nervous
  Striatum (neuron)  (TARGET) n/a