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Validation Experiment: Independent validation of Gong delivery platform using RNP-loaded nanocages to deliver CRISPR/Cas9 to mouse brain

PI:   Stephen A Murray, PhD 

Description: Delivery of CRISPR/Cas9 via RNP-loaded nanocages to the brain in Ai14 mice
Editing Assay: Editing efficiency calculated by counting the number of Edited Neurons (NeuN+/GFP+ and TdTomato+/RFP+) out of the total number of neurons (NeuN+/GFP+) in a defined region of interest in the brain, expressed as a percentage of neurons in the ROI.
Download: Submitted files
Analyze Data Sets Available for this Experiment
View Tissues:
 Nervous
  • Striatum (neuron)  (TARGET)

    • Organ System Overview

     
    Connective Tissue
    Reproductive
    Renal/Urinary
    Endocrine
    Haemolymphoid
    Gastrointestinal
    Liver and Biliary
    Respiratory
    Cardiovascular
    Musculoskeletal
    Integumentary
    Nervous
    Sensory
    		NC-CPP Males
    		NC-CPP Females
    		NC-RVG Males
    		NC-RVG Females
    		NC No Ligand Male
    		NC No Ligand Female
    Legend:  
    		 Delivery Efficiency
    		 Editing Efficiency
    		 Biomarker Detection
    		 Target Tissue
    		 Not Available