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Experiment: Shuttle peptides enable in vivo gene editing with Cas9 and Cas12a RNP in mouse airway epithelia

PI:   Paul B McCray, Jr, MD 
 

In vivo shuttle peptide delivery of Cas9 and Cas12a RNPs in mouse airway epithelia. Gene editing was quantified by the GFP+ cells in large and small airways following 1 delivery of GFP protein by GFP positive cells compared to DAPI stained cells.
Editing Assay: - Quantitation of GFP+ cells in large and small airways following 1 delivery of GFP protein by GFP positive cells compared to DAPI stained cells.

Organ System Overview
Legend:  
Delivery Efficiency
Editing Efficiency
Target Tissue
Not Studied


 
S10, Cas9
S10, Cas12a
 

 
Analyze Data Sets Available for this ExperimentDeliveryEditing
Respiratory
  Epithelium of bronchiole  (TARGET) n/a
  Epithelium of main bronchus  (TARGET) n/a